Overview

This is a practical introduction to the techniques of neural transplantation in mammalian brain tissue. It provides a detailed description of the techniques, written by acknowledged experts in the field, with practical details and hints complementing the underlying principles. Each chapter identifies the equipment needed, the preparations to be made in advance and step-by-step protocols for each procedure. All aspects of neural transplantation surgery are covered, from staging and dissection of embryonic CNS tissues, through the preparation of tissues for implantation, to the transplant surgery itself. A variety of different methods for solid and cell suspension transplantation are covered. Specialized chapters consider genetic engineering of cells, labelling of grafts, and other aspects of tissue manipulation in culture prior to implantation; implantation of PNS and gilal tissues; transplantation in neonatal animals, including primates; handling of human embryonic tissues for transplantation and immunological considerations. The book should be of interest to neuroscientists studying neural development, anatomical plasticity, functional organization and recovery in the mammalian CNS and to neurologists and neurosurgeons interested in developing clinical applications of neural transplantation. It should be stressed that these techniques are experimental and not for clinical use yet.

Full Product Details

Author:   S. B. Dunnett ,  Anders Bjorklund
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   98
Dimensions:   Width: 15.00cm , Height: 1.90cm , Length: 23.00cm
Weight:   0.570kg
ISBN:  

9780199632862

ISBN 10:   0199632863
Pages:   229
Publication Date:   01 August 1992
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

Staging and dissection of rat embryos, S.B. Dunnett; grafting genetically modified cells within the rat CNS, M.D. Kawaja et al; neural transplantation in adult rats, A. Bjorklund and S.B. Dunnett; intracerebral transplantation to immature hosts, R.D. Lund and K.T. Yee; the use of peripheral nerve grafts to study CNS regeneration, M. Vidal-Sanz et al; transplantation of glial cells into areas of demyelination in the adult rat spinal cord, W.F. Blakemore and A.J. Crang; neural transplantation in primates, L.E. Annett and R.M. Ridley; dissection, preparation and implantation of human embryonic brain tissue, P. Brundin; immonological considerations in neural transplantation, R.D. Lund and R. Bannerjee; identifying grafted cells, J, Cadusseau and M. Peschanski.

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