Overview

The mechanisms that govern the development of the neural circuitry are still largely unknown. It has not yet been clearly established to what extent early cortical differentiation depends on environmental or genetic factors. The first part of this book reports on findings of transplantation studies, performed in newborn recipient rats, in which these developmental issues are addressed. In humans, the cerebral cortex can be affected by a variety of diseases, hence several experimental studies were undertaken to determine to what extent transplantation of cortical neurons could be proven a useful treatment for cerebral cortical damage. The second part deals with the functional aspects of transplantations in adult recipient rats.

Full Product Details

Author:   Afsaneh Gaillard ,  Frederic Gaillard ,  Michel Roger
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   148
Dimensions:   Width: 15.50cm , Height: 0.50cm , Length: 23.50cm
Weight:   0.200kg
ISBN:  

9783540642527

ISBN 10:   3540642528
Pages:   86
Publication Date:   20 May 1998
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1 Transplantation of Embryonic Cortex into Newborn Host Cortex: A Means to Study Neural Development.- 1.1 Introduction.- 1.2 Materials and Methods.- 1.3 Early Specification of Neocortical Efferent Projections: The Homo- or Heterotopic Transplantation Paradigm.- 1.4 Conclusion.- 2 Transplantation of Embryonic Cortex into the Damaged Cortex of Adult Rats.- 2.1 Introduction.- 2.2 Transplantation into the Frontal Cortex: Anatomical, Metabolic, and Behavioral Aspects.- 2.3 Transplantation into the Occipital Cortex: Electrophysiological and Anatomical Aspects.- 2.4 Conclusion.- 3 Summary.- 4 References.

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