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Objective: The aim of this work was to study the predictive factors of HR to neoadjuvant treatment of locally advanced CR in Tunisian patients.Methods: Retrospective study of patients with CR operated after neoadjuvant radiochemotherapy (RCT). HR was assessed according to Dworak's TRG, whose five grades were subsequently grouped into two categories: Response Group (R) for TRG3 and 4 and No Response Group (PR) for TRG 0, 1 and 2.Results: The study included 88 patients with a mean age of 60 years. The site of CR was the middle rectum in 63% of cases. Node invasion was noted in 52 patients (59%). The R group comprised 29 patients (33%) and the PR group 59 patients (67%). In multivariate analysis, predictive factors for HR were age

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