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Author:   Stephen P. Stanforth (School of Applied Sciences, University of Northumbria, UK)
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell
Dimensions:   Width: 21.10cm , Height: 0.90cm , Length: 29.70cm
Weight:   0.508kg
ISBN:  

9781405145626

ISBN 10:   1405145625
Pages:   148
Publication Date:   26 June 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Section 1: Introduction. 1.1 Primary and Secondary Metabolites. 1.2 Properties and Purpose of Secondary Metabolites. Section 2: Acetyl Coenzyme A: A Key Biological Intermediate. 2.1 What is Acetyl Coenzyme A? 8. 2.2 Comparison of Organic and Acetyl Coenzyme A Reactions. 2.3 Malonyl Coenzyme A – A Partnership with Acetyl Coenzyme A. 2.4 How is Acetyl Coenzyme A Used in Biosynthesis?. Section 3: Biosynthesis of Fatty Acids. 3.1 What are Fatty Acids?. 3.2 Occurrence and Function of Fatty Acids. 3.3 Biosynthesis of Saturated Straight-Chain Fatty Acids. 3.4 Biosynthesis of Saturated Branched Fatty Acids. 3.5 Mono-unsaturated Fatty Acids. 3.6 Poly-unsaturated Fatty Acid. 3.7 Oxygenated Fatty Acids. 3.8 β-Oxidation. Section 4: Biosynthesis of Polyketides. 4.1 What are Polyketides?. 4.2 The Chemistry of 1,3-Dicarbonyls: Keto–Enol Tautomerism. 4.3 The Chemistry of 1,3-Dicarbonyls: Condensation Reactions. 4.4 Polyketide Cyclizations: Formation of Unsaturated Products. 4.5 Secondary Structural Modifications During Polyketide Cyclizations. 4.5.1 Alkylation. 4.5.2 Reduction. 4.5.3 Oxidation. 4.5.4 Decarboxylation. 4.5.5 Modifications to the Carbon Skeleton. 4.6 Alkaloids Derived from Polyketides. 4.7 The Use of Isotopes in the Elucidation of Biosynthetic Pathways. Section 5: The Shikimic Acid Pathway. 5.1 Introduction. 5.2 Transamination. 5.3 Biosynthesis of Natural Products Derived from Cinnamic Acid. 5.4 Lignans. 5.5 Biosynthesis of Alkaloids. 5.5.1 Decarboxylation of Amino Acids and α-Keto Acids. 5.5.2 Pictet–Spengler Reaction. 5.5.3 Alkaloids Derived from Tryptophan. 5.5.4 Alkaloids Derived from Tyrosine. Section 6: Terpenes. 6.1 What are Terpenes?. 6.2 Carbocations as Intermediates in Terpene Biosynthesis. 6.2.1 Hydride Shifts. 6.2.2 Alkyl Shifts. 6.2.3 Cyclizations. 6.3 Termination of Carbocations. 6.3.1 Loss of a Proton. 6.3.2 Addition of Water. 6.4 Terpene Biosynthesis. 6.4.1 Biosynthesis Initiated by Heterolysis of Pyrophosphates. 6.4.2 Biosynthesis from ‘Dimers’ of Pyrophosphates. 6.4.3 Biosynthesis Initiated by Protonation or Epoxidation of an Alkene. Section 7: Natural Products Derived from Amino Acids. 7.1 Alkaloids. 7.2 Penicillins and Related Compounds 1.1 Primary and Secondary Metabolites. 7.3 Macrocyclic Peptides. 7.4 Porphyrins. Section 8: Answers to Problems. Section 9: Further Reading. Index

Reviews

"""The author has successfully steered a course that charts the main chemical aspects of natural products and their biosynthesis, without becoming unduly enmeshed in biological aspects of the subject, and this is a strategy that will very well suit the target audience....The book is well balanced in its coverage, sensibly treating the fuzzy boundary between primary and seconday metabolism....this is a valuable addition to the 'at a glance' stable, and will find a welcome home in undergraduate chemistry curricula in the UK and abroad."" Chemistry World ""The undergraduate student who wants to know the mechanistic chemistry of biosynthesis is well served by this book."" Education in Chemistry"

The author has successfully steered a course that charts the main chemical aspects of natural products and their biosynthesis, without becoming unduly enmeshed in biological aspects of the subject, and this is a strategy that will very well suit the target audience...The book is well balanced in its coverage, sensibly treating the fuzzy boundary between primary and seconday metabolism...this is a valuable addition to the 'at a glance' stable, and will find a welcome home in undergraduate chemistry curricula in the UK and abroad. Chemistry World The undergraduate student who wants to know the mechanistic chemistry of biosynthesis is well served by this book. Education in Chemistry

The author has successfully steered a course that charts the main chemical aspects of natural products and their biosynthesis, without becoming unduly enmeshed in biological aspects of the subject, and this is a strategy that will very well suit the target audience....The book is well balanced in its coverage, sensibly treating the fuzzy boundary between primary and seconday metabolism....this is a valuable addition to the 'at a glance' stable, and will find a welcome home in undergraduate chemistry curricula in the UK and abroad. Chemistry World The undergraduate student who wants to know the mechanistic chemistry of biosynthesis is well served by this book. Education in Chemistry

The author has successfully steered a course that charts the main chemical aspects of natural products and their biosynthesis, without becoming unduly enmeshed in biological aspects of the subject, and this is a strategy that will very well suit the target audience....The book is well balanced in its coverage, sensibly treating the fuzzy boundary between primary and seconday metabolism....this is a valuable addition to the 'at a glance' stable, and will find a welcome home in undergraduate chemistry curricula in the UK and abroad. Chemistry World The undergraduate student who wants to know the mechanistic chemistry of biosynthesis is well served by this book. Education in Chemistry

Author Information

Stephen Stanforth is a Reader in the School of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK.

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