Overview

M r b r known t human civilization du to their b n f l and l th l ff t . Wh n th mb t relation f microorganisms goes beyond th l m t, th m u th g n nf t n and d , u ng d m g to th body nd m t m l d ng t d th: th is a m j r n rn ng issue especially in developing countries. Th determination of x t site f nf t n n th b d very r t l for ur ng the pathogenesis u d b b t r t th r early t g . Ant m r b l g nt ll nt b t , wh h r th r bt n d from n tur l ur r thr ugh total nth t r dur , are practiced g n t pathogens. Ant b t m b bt n d n tur ll fr m living organism (e.g., fung , actinomycete, nd bacillus species), r r d nth t ll and semisynthetically n th l b r t r . It m h n m f action d v d d nt two spectrums (n rr w and br d-r ng tr ). Br d- trum nt b t act against both Gr m- t v nd Gram-negative b t r . A g d nt b t h uld h v th f ll w ng characteristics: l ng shelf life, n nt x t hum n b d , lubl n th b d flu d, l w cost, show l ng-l t ng nt b t r l effect, nd l w b l t of bacterial r t n to the g nt. However, ll th standard r m t r for n d l antibiotic r difficult t m t, wh l developing nth t antibacterial agents th t th reason a b g thr t being felt from th g n bacterial resistance wh h is th main ubl h lth-r l t d u , all v r th globe. Th appeared dur ng the l t d d n a m r prominent way wh h m nl r g n t d either due t wrong identification f b t r l strain nd prescription f nt b t r du t mb l n u of nt b t r l g nt . The tr n m n f bacterial resistance m ng th nd v du l and r the g l g l border n way of antimicrobial resistance. Furth r, n th th r w , t handle the b t r l r t n thr t, the pipeline of the d v l m nt f n w nth t nt b t r l g nt gradually dr ng u . And it m ght b bl , on the b f continuously increasing l v l of bacterial r t n ; t some t g pathogenic b t r h lt antibiotic therapy-that stage w ll b n t good n the h t r f hum n b ng

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