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9781849734042

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As the title indicates, this book focuses on nanofluidics with a few topics in the broader areas of nanoscience and nanotechnology. Excellent coverage of the defining features of nanofluidics that separates it from larger scale fluidic systems is achieved. The critical dimension for nanochannels and nanocapillaries are the height and diameter, respectively. As the critical dimension approaches the size of large biomolecules and the Debye layer thickness, the increased wall interactions and increased role of surface give rise to unusual phenomena not observed at larger scales. When the diameter of a nanopore or nanowell approaches the molecular diameter, this nanoconfinement provides new approaches to biomolecular detection and analysis. The basis of these uniquely nanoscale phenomena and the new frontiers in sensing and analysis that they give rise to are well covered within this book. This nine-chapter book has a total of 198 pages. The chapters of this book include the following: Transport of Ions, DNA polymers, and microtubules in the nanofluidic regime; Biomolecule separation, concentration, and detection using nanofluidic channels; Particle transport in micro and nanostructured arrays: asymmetric low Reynolds number flow; Molecular transport and fluidic manipulation in three dimensional integrated nanofluidic networks; Fabrication of silica nanofluidic tubing for single molecule detection; Single molecule analysis using single nanopores; Nanopore-based optofluidic devices for single molecule sensing; Ion-current rectification in nanofluidic devices; and Nanopillars and nanoballs for DNA analysis. Since nanofluidics is still a young area of research, there are only a few books which cover nanofluidics. While other titles present a more systematic fundamental description of the unique fluidic and surface effects encountered in nanofluidics, this book provides a wider range of both fundamental and applied topics. This wider range of topics provides the reader an introduction to many exciting and active areas of research in nanofluidics. Because the book is a compilation of chapters written by experts in the field, it lacks the flow of a text carefully developed by a one or a few authors. However, the pro of this approach is that the reader gets a wider range of many of the key areas of active research presented by leading researchers in these areas. This book is recommended for the reader wanting to get a rapid look into a number of active research areas in nanofluidics while covering the fundamental processes that make nanofluidics unique. This book is excellent for scientists who are new to nanofluidics or want to expand their knowledge of nanofluidics, and is well-suited for graduate students and exceptional undergraduate students. The book fills a gap in the current literature by providing both coverage of the fundamental processes that give rise to unique nanoscale phenomena while presenting a wide range of research topics and applications of nanofluidics. Although all of the current applications of nanofluidics cannot be covered in a single book, an excellent array of topics is provided. Readers will enjoy the presentation of many nanoscale phenomena by top researchers in these areas and the numerous citations provided will aid in further studies. * Analytical and Bioanalytical Chemistry * Recommended for the reader wanting to get a rapid look into a number of active research areas in nanofluidics. * Analytical and Bioanalytical Chemistry *

Recommended for the reader wanting to get a rapid look into a number of active research areas in nanofluidics while covering the fundamental processes that make nanofluidics unique. -- Aaron Timperman * Analytical and Bioanalytical Chemistry *

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Derek Stein was a post-doctoral research in the Molecular Biophysics group of Cees Dekker at the Delft University of Technology, where I studied the properties of DNA polymers and ionic fluids confined to nanofluidic channels (2003-2006). My Ph.D. thesis research was performed in the group of Jene Golovchenko at Harvard University, where I was involved in making the first solid state nanopores, and then using them to study individual DNA molecules. This was a joint project with the Molecular Biology group of Daniel Branton (1997-2002). After my Ph.D. I spent three months in the Life Science Technologies Laboratory at Agilent Technologies transferring nanopore technology to them by developing an industrial ion-beam-sculpting apparatus (2002).

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