Overview

This book focuses on three of the main categories of myeloproliferative neoplasm: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Relevant laboratory and clinical advances are comprehensively covered, and great emphasis is placed on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic  approaches, the value and limitations of mutation screening for diagnostic and  prognostic purposes, risk stratification in terms of both survival and other  disease complications such as leukemic transformation and thrombosis, and  modern therapeutic strategies, including conventional drugs, allogeneic stem cell  transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.

Full Product Details

Author:   Tiziano Barbui ,  Ayalew Tefferi
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2012
Weight:   0.651kg
ISBN:  

9783662520277

ISBN 10:   3662520273
Pages:   240
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Biology: Update Do we need biology studies for patient management? Gerneral Issues in the Management of MPNs: Critical Issues about the Diagnosis of MPNs Patient's Information and Examinations Needed before Planning Therapy Specific Issues of Treatment in PV and ET: Risk classification Goal of Therapy First-line Therapy and Monitoring the Response in the Individual Patient Primary and Secondary Antithrombotic Prophylaxis When to change Therapy: Second Line Options The Evolution in Myelofibrosis and Leukemia Treatment of PMF: Current Clinical Needs Risk Stratification Goal of Therapy: Palliation and Curative Research Issues and Perspectives: New drugs Ongoing Clinical Trials How to Design Clinical Studies in Rare Diseases

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Author Information

The discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative myeloproliferative neoplasms has stimulated a number of questions regarding the diagnosis, prognosis, and treatment of polycythemia vera, essential thrombocythemia, and primary myelofibrosis. This book provides evidence-based reviews and expert consensus results concerning the key clinical issues for patient management. Practical recommendations are provided for the optimization and standardization of management of all three types of myeloproliferative neoplasm. Risk stratification, treatment goals, and first- and second-line therapies are discussed in detail, and other relevant diagnostic and research issues are also addressed. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.

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