Overview

Myelopeptides are a new class of endogenous bioregulatory peptides. Each has its own definite immunoregulatory activity and differs in their final effects and mechanisms of action. Myelopeptides act as immunocorrectors and thus prevent the development of immunodeficiency states. They have an antitumor effect which contributes to the retention of active immune defense in the tumor-bearing body. The ability of myelopeptides to induce terminal cell differentiation in hemopoietic disorders (in particular, in leukemia) is demonstrated. The protective effect of a single myelopeptide in bacterial contagion of animals, which is due to the stimulation of macrophage phagocytosis, is established. In this book, the concept of the general biological value of cytokines, including peptide endogenous regulators, is discussed. Myelopeptides are promising in the development of a new generation of medicinal preparations because of their endogenous origin, low molecular weight, directed action and absence of side effects.This book is intended for those interested in medical and biological problems: lecturers and students in medical and biological universities, scientists and researchers from medical and biological laboratories, and other professionals involved in medical and biological research.Contents: New Immunoregulatory Bone Marrow Peptides, Myelopeptides: Discovery of Bone Marrow Factor(s)Myelopeptides: A Group of Bone Marrow Bioregulatory MediatorsMyelopeptides and Human Immune Reactions Individual Myelopeptides: Structure, Function, Mechanism of Action: Isolation, Identification and Synthesis of MyelopeptidesMP-1 is a Myelopeptide with Immunocorrective ActivityMP-2 is a Myelopeptide with Antitumor EffectConformational Study of MP-1 and MP-2MP-3 is a Myelopeptide Stimulating MacrophageMP-4 is a Cell Differentiation FactorMyelopeptides: A New Class of Endogenous Bioregulatory PeptidesReadership: Students and researchers in biochemistry, immunology and hematology.

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9781299614284

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