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Author:   G. E. Paget
Publisher:   Kluwer Academic Publishers Group
Imprint:   Kluwer Academic Publishers
Weight:   0.500kg
ISBN:  

9780852002414

ISBN 10:   0852002416
Pages:   231
Publication Date:   June 1979
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Section One General Background to Mutagenesis Studies.- 1 Mutagenesis - the significance of DNA damage for man.- 2 The role of Drosophila in mutagen testing.- Discussion.- Section Two Bacterial Tests for Mutagenesis.- 3 A strategy to minimize human exposure to environmental chemicals causing cancer and genetic birth defects.- 4 Practical experience in testing unknowns in vitro.- 5 Induced mutation in micro-organisms: validity for estimating risk to man.- Discussion.- Section Three Other Mutagenesis Test Systems.- 6 Sub-mammalian tests other than the Ames test for mutagenesis.- 7 Cytogenetic aspects of mutagenicity testing.- 8 Cell transformation assays.- 9 Implications of carcinogenicity.- Discussion.- Section Four General Implications of Mutagenesis.- 10 Extrapolation of mutagenic test results to man.- 11 Tests for mutagenesis from a regulatory point of view.- Discussion.- Round Table Discussion.- Concluding Remarks.

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