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By correctly diagnosing a disease, perceiving its nature, gaining insight into its cause, any uncertainty is ended. The diagnosis clears the way to its cure or an alleviating of its effects. No diagnosis of multiple sclerosis, MS, ever brought such a relief. It is ominous a verdict, arrived at in cold calculations of incapacitation times, in counting lesions identified neither as for their character nor their origin. The idea of opening up extracranial obstructions to the venous drainage of brain and spine observed in patients with a diagnosis of MS cast a flickering light on the scene. Baffling recoveries alternated with unsatisfactory outcomes. But nobody made out why this has been so. Who takes a closer look into the earliest days of MS research sees that MS has not always been just a mysterious entity. That it had unmistakable features of its own. In pursuing the given strands of evidence up to the most recent advances in MR imaging, a well defined MS agent begins to emerge: The retropulsive venosome. Those who elucidate the nature and activities of these potentially ruinous venous bodies are expected to solve the basic problems of not only CCSVI and MS research.

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