Overview

Mucosal Barriers and Host-Microbiota Interplay: Dysbiosis to Barrier Dysfunction, a volume in Elsevier's new series Hot Topics in Physiology, provides an in-depth exploration of mucosal barriers, including their structure, establishment, and consideration of different diseases and intervention strategies. Published in association with the International Union of Physiological Sciences (IUSP), this is an ideal reference for those researching or studying biology and medicine, particularly gastroenterology. Biotechnological companies working on metagenomics sequencing and analysis may also find this volume useful. As a massive load of commensal microbes, consisting of bacteria, viruses, and fungi resides in the gastrointestinal tract and other mucosal surfaces, collectively termed microbiota, this book provides an update on new and existing knowledge. Mucosal barriers, including the epithelial layers and immune cells act as the frontline to strategically confine these microorganisms and prevent the entry of microbes into the body proper.

Full Product Details

Author:   Linda Chia-Hui Yu, PhD (Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443403064

ISBN 10:   0443403066
Pages:   300
Publication Date:   01 June 2026
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. Host Barriers against Microbiota: Traditional Views and Recent Advances 2. Neonatal Establishment of Microbiome Ecosystem and Intestinal Barrier: How Developmental Programming of Gut Microbiota Impacts Adult Disease Progression 3. Epithelial Junctional Proteins for Physical Defense, Cell-Cell Contact, and Polarity Complex 4. Unconventional Roles of Tight Junctions in Cell Survival and Ion Transport 5. Epithelial Microvilli and Transcellular Permeability in the Cause-and-Effect Relationship between Barrier Dysfunction and Microbiota Dysbiosis 6. Wound Healing and Barrier Integrity: Cellular and Molecular Players in Gastric Mucosal Repair 7. Mucosal Pathophysiology: The Role of Gut Microbiota Biofilms during Host-Pathogen Interplay 8. Antagonism between Gut Microbiota Modulates the Progression of Chronic Hepatitis 9. The Role of Microbiome-Mucosal Barrier Interactions in Neoplastic Diseases 10. The Interplay of Gut Microbiota and Energy Homeostasis in Obesity-related Diseases 11. Refining the Role of Gut Microbiota in the Developmental Programming of Cardiovascular Kidney Metabolic Syndrome 12. Interrelationship between Intestinal Immune Cells and Barrier Function in the Development of Neurodegenerative Diseases 13. Intestinal Epithelial Cells: Gatekeepers of Gut-Brain Axis, Microbiome, and Beyond 14. Epithelial Barriers and Microbiota-Gut-Brain Axis, Microbiome, and Beyond 15. The Role of Gut Microbiota in Cancer Development and Translational Modulation Strategies 16. Diagnostic and Therapeutic Potentials Targeting the Interplay of Host Barriers and Microbiota in Human Diseases 17. The Dietary Restoration of Intestinal Barrier Function by Nutrient-Sensing Receptors 18. Dietary Factors and Next-Generation Probiotics for Microbiota Eubiosis and Barrier Fortification

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Author Information

Dr. Yu reeived her PhD in 2002 from McMaster University in Ontario, Canada. She joined the National Taiwa University College of Medicine, Taipei, Taiwan in 2005, becoming full Professor in 2016. Her lab investigates pathophysiological mechanisms of intestinal epithelial biology and mucosal immuno-oncology. The research interest is focused on host-microbe interaction for regulation of epithelial barrier function and tumorigenesis in the gastrointestinal tract. She's received many honors and awards, and is currently a member of the Chinese Physiology Society (CPS), the American Physiology Society (APS) and the American Gastroenterology Association (AGA). Additionally, Dr. Yu is a Council Member of the International Union of Physiological Sciences (IUPS.

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