Overview

Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit­ nessed a quantum leap in our knowledge, due to technological improve­ ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno­ type. Nevertheless, the recent progress in genetics will allow us to contem­ plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop­ mental biology. The purpose of the present book is to provide an overview that syn­ thesizes up-to-date information on selected aspects of mouse brain devel­ opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

Full Product Details

Author:   Andre M. Goffinet ,  Pasko Rakic
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2000
Volume:   30
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.545kg
ISBN:  

9783642536847

ISBN 10:   3642536840
Pages:   339
Publication Date:   28 July 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction.- Mapping Genes that Modulate Mouse Brain Development.- Genetic Interactions During Hindbrain Segmentation in the Mouse Embryo.- Neurogenetic Compartments of the Mouse Diencephalon and Some Characteristic Gene Expression Patterns.- Neuronogenesis and the Early Events of Neocortical Histogenesis.- Programmed Cell Death in Mouse Brain Development.- Neurotrophic Factors: Versatile Signals for Cell-Cell Communication in the Nervous System.- Growth Factors' Influences on the Production and Migration of Cortical Neurons.- Signalling From Tyrosine Kinases in the Developing Neurons and Glia of the Mammalian Brain.- The Role of the p35/cdk5 Kinase in Cortical Development.- The Reelin Signalling Pathway and Mouse Brain Development.- The Subpial Granular Layer in the Developing Cerebral Cortex of Rodents.- Development of Thalamocortical Projections in Normal and Mutant Mice.

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