Overview

Deglutition or a swallow begins as a voluntary act in the oral cavity but proceeds autonomously in the pharynx and esophagus. Bilateral sequenced activation and inhibition of more than 25 pairs of muscles of mouth, pharynx, larynx, and esophagus is required during a swallow. A single swallow elicits peristalsis in the pharynx and esophagus along with relaxation of upper and lower esophageal sphincters. Multiple swallows, at closely spaced time intervals, demonstrate deglutitive inhibition; sphincters remain relaxed during the entire period, but only the last swallow elicits peristalsis. Laryngeal inlet closure or airway protection is very important during swallow. Upper part of the esophagus that includes upper esophageal sphincter is composed of skeletal muscles, middle esophagus is composed of a mixture of skeletal and smooth muscles, and lower esophagus, including lower esophageal sphincter, is composed of smooth muscles. Peristalsis progresses in seamless fashion, despite separate control mechanism, from the skeletal to smooth muscle esophagus. The esophagus's circular and longitudinal muscle layers contract synchronously during peristalsis. Sphincters maintain continuous tone; neuromuscular mechanisms for tonic closure in the upper and lower esophageal sphincters are different. Lower esophageal sphincter transient relaxation, belching mechanism, regurgitation, vomiting, and reflux are mediated via the brain stem.

Full Product Details

Author:   Ravi Mittal
Publisher:   Morgan & Claypool Publishers
Imprint:   Morgan & Claypool Publishers
Dimensions:   Width: 18.70cm , Height: 0.40cm , Length: 23.50cm
Weight:   0.161kg
ISBN:  

9781615043330

ISBN 10:   1615043330
Pages:   84
Publication Date:   30 December 2010
Audience:   General/trade ,  General
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
We will order this item for you from a manufatured on demand supplier.

Table of Contents

Introduction Central Program Generator and Brain Stem Pharynx-Anatomy, Neural Innervation, and Motor Pattern Upper Esophageal Sphincter Neuromuscular Anatomy of Esophagus and Lower Esophageal Sphincter Extrinsic Innervation: Parasympathetic and Sympathetic Interstitial Cells of Cajal Recording Techniques Motor Patterns of the Esophagus-Aboral and Oral Transport Deglutitive Inhibition and Muscle Refractoriness Peristalsis in the Circular and Longitudinal Muscles of the Esophagus Neural and Myogenic Mechanism of Peristalsis Central Mechanism of Peristalsis-Cortical and Brain Stem Control Peripheral Mechanisms of Peristalsis Central Versus Peripheral Mechanism of Deglutitive Inhibition Neural Control of Longitudinal Muscle Contraction Modulation of Primary and Secondary Peristalsis Neural Control of Lower Esophageal Sphincter and Crural Diaphragm Lower Esophageal Sphincter Swallow-Induced LES Relaxation Crural Diaphragm Contribution to EGJ and Neural Control Transient LES Relaxation and Pharmacological Inhibition Compliance of the EGJ References

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