Overview

The kidney involvement in monoclonal gammopathies is a fascinating field of research and of great concern to clinical practice. The book is divided into four parts. The first one is devoted to ""the culprits"" and includes contributions from leading investigators in B-cell proliferations, immunoglobulin synthesis, secretion and structure, light chain uptake and metabolism in the kidney. The second and third parts are devoted to ""the victims"": the tubule and the glomerulus. New insights into pathophysiology, clinical and histological features, treatment of renal lesions and therapy of B-cell proliferations are reported in myeloma cast nephropathy, Fanconi's syndrome, Randall-type monoclonal immunoglobulin deposition disease and non amyloid organized monoclonal immunoglobulin deposits. In the last part, immunoglobulinic amyloidosis is considered with a round table devoted to stem cell transplantation and new promising therapies in AL amyloidosis.

Full Product Details

Author:   G. Touchard ,  Dr Aucouturier ,  O. Hermine ,  Pierre Ronco
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2003
Weight:   0.539kg
ISBN:  

9789048161997

ISBN 10:   9048161991
Pages:   300
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

I: The Culprits: the Plasma Cell Dyscrasias.- 1 Physiopathology of malignant B cell lymphoproliferations.- 2 Immunoglobulin synthesis and secretion.- 3 Immunoglobulin decreased solubility diseases: pathologies of the V domains?.- 4 Megalin, cubilin and immunoglobulin light chains: receptor-mediated uptake of light chains in kidney proximal tubule.- II: The Victim: the Tubule.- 5 Pathophysiology of myeloma kidney.- 6 Myeloma cast nephropathy: clinical presentation.- 7 New therapeutic approaches for the myeloma patient with and without renal failure.- 8 Adult Fanconi’s syndrome due to monoclonal immunoglobulin light chains: an underdiagnosed disease with unexpected clinical and pathologic heterogeneity.- 9 Monoclonal immunoglobulin light chains associated to Fanconi’s syndrome.- III: The Victim: the Glomerulus.- 10 Ultrastructural pattern and classification of renal monoclonal immunoglobulin deposits.- 11 Morphological aspects in light chain deposition disease.- 12 Renal monoclonal immunoglobulin deposition disease (MIDD): the Columbia experience.- 13 Monoclonal cryoglobulinemia kidney.- 14 Fibrillary glomerulonephritis: defining the disease spectrum.- 15 Glomerulonephritis with organized immunoglobulin deposits: fibrillar and microtubular deposits are associated with distinct immunological features.- IV: Immunoglobulins Amyloidosis.- 16 Clinical features and management of amyloidosis.- 17 Fibrillogenesis and therapy of amyloidosis: an equilibrium approach.- 18 Immunoglobulin light chain amyloidosis and the kidney.- 19 Treating primary systemic amyloidosis with stem cell transplantation: outcomes in renal amyloidosis.- 20 Prognostic factors for survival and response after high-dose therapy and autologous stem cell transplantation in systemic AL amyloidosis: a reporton 21 patients.- 21 Presentation of the French multicentre randomized trial comparing intensive and conventional treatment for AL amyloidosis.- 22 Amyloidosis: Round Table.- Oral communications.- Poster communications.

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