Overview
Mutations can cause diseases by producing functionally altered proteins, and understanding the exact nature of diseases from the structures of the proteins involved is the aim of this book. It provides insights into the structures and functions of 130 of of the most important biomolecules and their interactions with other endogenous or exogenous molecules. These interactions are illustrated by three-dimensional images of their atomic structures rather than by abstract formulas or acronyms. The author has compiled a collection of molecules which he has visualized in pictures by applying molecular modelling software to their atomic coordinate files (deposited in the Brookhaven Protein Data Bank, PDB). Together with short explanatory texts they provide the reader with a deepened understanding of biological phenomena in the normal as well as the diseased organism. Following a didactic approach, this book distills the most important facts, making it accessible to the non-specialist reader as well; at the same time it serves as a guide to the vast amount of information stored in authoritative Internet databases such as the PDB and OMIM (Online Mendelian Inheritance in Men) databanks. For an in-depth study of structures and genetic diseases, an enhanced index listing databank accession numbers, gene name and chromosomal location of each molecule under consideration is added, which can also be accessed online on the book's website. A list of useful Internet resources rounds off the practical value of this textbook. Mutations can cause diseases by producing functionally altered proteins, and understanding the exact nature of diseases from the structures of the proteins involved is the aim of this book.
Full Product Details
Author: S. Schwarz
Publisher: S Karger AG
Imprint: S Karger AG
Dimensions:
Width: 21.60cm
, Height: 1.30cm
, Length: 28.00cm
Weight: 0.900kg
ISBN: 9783805573955
ISBN 10: 3805573952
Pages: 144
Publication Date: 24 September 2002
Audience:
College/higher education
,
Professional and scholarly
,
Undergraduate
,
Postgraduate, Research & Scholarly
Format: Hardback
Publisher's Status: Out of Print
Availability: Awaiting stock 
Table of Contents
Ligands - Small Molecules: Nonpeptidic ""Small Molecules"" - Calcium, Catecholamines, Morphine, Adenosine Phosphates, Steroids, Estrogens, Progesterone, Thyroid Hormones, Enzyme Inhibitors, DNA-Binding Substances, Carcinogens, Cytostatic Agents, Ionophores; Peptidic and Proteohormones; Peptidic Toxins. Pictorial Representation of Proteins: Ligand - Transforming Growth Factor-beta; Ligand-Binding Protein - Human Chorionic Gonadotropin Receptor. Ligand-Binding Proteins - Large Molecules: Enzymes; Membrane Receptors; Signal Transduction Proteins; Multimodular Adhesion Proteins; DNA-Binding Proteins - DNA/RNA-Processing Enzymes, Antibodies against DNA, DNA-Bending Proteins (HMG-Box Proteins), Transcription Factors, Tumour Suppressor Proteins, Telomere-Binding Proteins, Homeobox Proteins; Immunological Proteins - Antibodies and B-Cell Receptors, MHC Proteins, T-Cell Receptor, Immunophilins; Miscellaneous Macromolecules - Apolipoproteins, Crystallins, Collagens, Haemoglobin, Spectrin, Stress Proteins, Chaperones and Heat Shock Proteins, Proteasomal Proteins, Viral Coat Proteins.
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