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OverviewColorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease. Full Product DetailsAuthor: Kevin M. Haigis, Ph.D.Publisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2013 ed. Dimensions: Width: 15.50cm , Height: 2.30cm , Length: 23.50cm Weight: 6.679kg ISBN: 9781461484110ISBN 10: 1461484111 Pages: 316 Publication Date: 03 October 2013 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of ContentsPreface.- The Genetics of Colorectal Cancer.- Molecular Mechanisms of Colorectal Carcinogenesis.- The association between inflammation and colorectal cancer.- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease.- Mutational activation of KRAS and BRAF in colorectal cancer.- The PI3K pathway in Colorectal Cancers.- TGF-ß signaling pathway and colorectal cancer.- The Clinical Significance of Mutations in Colorectal Cancer.- Colorectal Cancer Genome and Its Implications.- Copy-Number Alterations in the Colorectal Cancer Genome.- Genome-wide association studies in colorectal cancer.- Future prospects for leveraging molecular information in the fight against colorectal cancer.- Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |