Overview

Molecular Neurosurgery with Targeted Toxins covers the basic science applications of targeted cytotoxins including suicide transport, immunolesioning and neuropeptide-toxin conjugates. Included are introductory considerations and background on the toxins followed by five chapters reviewing the use of the immunotoxin 192 IgG-saporin to lesion the cholinergic basal forebrain. The emphasis is on both how to use the various agents, as well as on practical applications where the targeted toxins have been used in experiments to provide new information not previously available by any other technique. This line of work has been highly successful, and as pointed out by the authors, has provided a valuable animal model of Alzheimer's disease.

Full Product Details

Author:   Ronald G. Wiley ,  Douglas A. Lappi
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2005 ed.
Dimensions:   Width: 15.50cm , Height: 2.10cm , Length: 23.50cm
Weight:   0.718kg
ISBN:  

9781588291998

ISBN 10:   1588291995
Pages:   312
Publication Date:   22 March 2005
Audience:   General/trade ,  Professional and scholarly ,  College/higher education ,  General ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

to Molecular Neurosurgery.- Ribosome-Inactivating Proteins.- Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin.- Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin.- 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System.- Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin.- Cortical Cholinergic Deafferentation Induces A? Deposition.- Chemical Dissection of Brain Glucoregulatory Circuitry.- Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin.- Saporin Conjugates and Pain.- The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness.- Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons.- B Fragment of Cholera Toxin Conjugated to Saporin.

Reviews

"""...a good purchase for most neuroscience and neurology libraries."" - Doody's Health Science Book Review Journal"

...a good purchase for most neuroscience and neurology libraries. - Doody's Health Science Book Review Journal

...a good purchase for most neuroscience and neurology libraries. - Doody's Health Science Book Review Journal

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