Overview

Discover the future of medicine in this extensively updated edition of the pioneering textbook, reflecting the rapid progress in the field Molecular medicine is a rapidly growing field, and the molecular basis of diseases can be used to develop therapeutic approaches in numerous other medical subfields. Research into molecular medicine has been used as the basis for gene therapy, precision medicine, and more. Molecular Medicine provides a fundamental overview of this cutting-edge, interdisciplinary field, incorporating modules from basic immunology to virology to new approaches. Now fully updated to reflect the exponential progress in biomedical research, it promises to put students on the leading edge of a revolution in the life sciences. Readers of the second edition of Molecular Medicine will also find: Detailed discussion of cutting-edge topics including cancer stem cells, mRNA vaccines, organs-on-a-chip, and more Professional artwork throughout Chapter summaries, exercises, and study questions for each chapter Molecular Medicine is ideal for graduate students in life sciences and medicine, as well as the lecturers and libraries that support them.

Full Product Details

Author:   Jens Kurreck (Berlin University of Technology (TUB), Germany) ,  Cy Aaron Stein (Hope Medical Center in Duarte, CA, USA)
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Edition:   2nd edition
Dimensions:   Width: 21.60cm , Height: 1.50cm , Length: 27.60cm
Weight:   0.680kg
ISBN:  

9783527352395

ISBN 10:   3527352392
Pages:   464
Publication Date:   23 April 2025
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1 Introduction 1.1 The Basics of Molecular Medicine 1.2 The Human Cell 1.3 DNA Replication and Gene Expression 1.4 Biological Communication 1.5 The Immune System 2 Methods in Molecular Medicine 2.1 DNA Microarrays 2.2 Quantitative Polymerase Chain Reaction 2.3 Next-Generation Sequencing 2.4 Proteomics 2.5 Animal Models in Biomedical Research 2.6 Alternatives to Animal Testing 2.7 Additional Methods 3 Genetic Disorders 3.1 Single-Gene Disorders 3.2 Polygenic Disorders 4 Molecular Oncology 4.1 Basics of Oncology 4.2 Selected Cancer Diseases 4.3 Oncolytic Virus Therapy 4.4 Cancer Stem Cells 4.5 Cancer Immunotherapy 5 Molecular Virology 5.1 The Basics of Virology 5.2 Vaccination 5.3 Detection of Viruses 5.4 Antiviral Therapy 5.5 Prions 6 Bacteria and Eukaryotic Pathogens 6.1 Bacteria 6.2 Eukaryotic Pathogens 7 Genomics and Proteomics 7.1 Whole Genome Sequencing 7.2 The Human Genome 7.3 Sequencing of Ancient DNA 7.4 Follow-up Initiatives of the Human Genome Project 8 Genetic Testing 8.1 Types of Genetic Tests 8.2 Chromosome Abnormalities 8.3 Molecular Diagnosis 9 Pharmacogenetics/Pharmacogenomics 9.1 Uptake and Transport of Drugs 9.2 Drug Metabolism 9.3 Drug Targeting 9.4 Drug Toxicity and Hypersensitivity 9.5 Drug Development and Individual Pharmacotherapy 10 Recombinant Protein Drugs 10.1 Production of Recombinant Proteins 10.2 Classes of Recombinant Drugs 11 Gene Therapy 11.1 Types of Gene Therapy 11.2 Methods of Gene Transfer 11.3 Tissue Speci¿city of Gene Transfer and Gene Expression 11.4 Applications of Gene Therapy 11.5 Genome Editing with CRISPR/Cas 11.6 Future Prospects 12 Stem Cells 12.1 Embryonic Stem Cells 12.2 Adult Stem Cells 12.3 Induced Pluripotent Stem Cells 12.4 Transdifferentiation and Direct Reprogramming 12.5 Differentiation of Stem Cells 12.6 Medical Applications of Stem Cells 13 Oligonucleotide-based Strategies 13.1 Antisense Oligonucleotides 13.2 RNA Interference 13.3 MicroRNAs 13.4 Aptamers, Decoy Oligonucleotides, and Immunostimulatory Oligonucleotides 14 Ethics in Molecular Medicine 14.1 The Basis of Bioethics 14.2 Fields of Application

Reviews

Ein sehr gut strukturiertes, übersichtliches und sehr aktuelles Lehrbuch mit sehr gut erklärenden Abbildungen. (Dr. Ursula Hoja, Paracelsus Medizinische Universität, Nürnberg)

Author Information

Jens Kurreck, PhD, is a full Professor for Applied Biochemistry at the Technische Universität Berlin (TUB), Germany. He studied biochemistry and philosophy at the Free University of Berlin (FUB) and completed his PhD at the TUB in 1998. His research focuses on 3D bioprinting, RNA technologies, and virology. He has received several awards for his research achievements and teaching activities. Cy Aaron Stein, PhD, is Emeritus Professor of Oncology and Experimental Therapeutics and Chair of Medical Oncology at the City of Hope Medical Center in Duarte, CA, USA. He received a PhD in chemistry from Stanford University and an MD degree at the Albert Einstein College of Medicine, NY, in 1982. He has received numerous awards, among them the 2023 Life Achievement Award of the Oligonucleotide Therapeutics Society and a Clinical Career Development Award of the American Cancer Society.

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