Overview

This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). As the word “idiopathic” indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.

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9784431562795

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Dr. Kazunari Kaneko obtained PhD in division of Medicine, Jyuntendo University, Japan in 1989. He started his career as bucho at the Ishioka Ishikai clinic in the same year. He went back to Jyuntendo University to be assistant professor in 1992. There He promoted to lecturer, and then associate professor. He moved to Kansai Medical University as full Professor in 2005. He is the top researcher in the field of Pediatric and Nephrology. He is the bourd member of the Japanese Society for Pediatric Nephrology, Japanese society of Pediatric Radiology, Japanese society of Pediatric Urology, and Japanese society of Pediatric Psychiatry and Nephrology.

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