Overview

Molecular Genetics of Inherited Eye Disorders provides an authoritative and up-to-date account of molecular genetic advances in a wide spectrum of genetic eye disorders, and forms the second volume in the Modern Genetics book series. The field has produced some dramatic and often unexpected findings in recent years ranging from the elegant unravelling of the molecular basis of colour vision defects to the subtle complexity of the retinoblastoma gene. The role of crystallins in congenital cataract and of the rhodopsin molecule in retinitis pigmentosa are discussed, illustrating the importance of the candidate gene approach to genetic eye disease. Reverse genetic approaches to the cloning of genes responsible for aniridia and choroideremia exemplify the power of the new genetic techniques and signal the start of the next experimental phase, in which the functional characterization of identified genes begins.

Full Product Details

Author:   Alan F. Wright ,  Alan F. Wright ,  B. Jay
Publisher:   Harwood-Academic Publishers
Imprint:   Harwood-Academic Publishers
Volume:   v. 2.
Dimensions:   Width: 17.80cm , Height: 3.50cm , Length: 25.40cm
Weight:   1.451kg
ISBN:  

9783718654932

ISBN 10:   3718654938
Pages:   552
Publication Date:   01 December 1994
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface to the Series Preface Contributors Background to Molecular Genetic Principles and Techniques M. B. Gorin and A. F. Wright INVERTEBRATES Retinal Degeneration Mutants of Drosophila W. L Pak VERTEBRATES CHOROID AND RETINA Diagnosis in Inherited Retinal Disorders A. C. Bird and B. Jay Human Albinism and Mouse Models R. A. King, I. J. Jackson and W. S. Oetting Inherited Retinal Degenerations in the Mouse D. B. Farber and M. Danciger Autosomal Dominant Retinitis Pigmentosa P. Humphries, P. Kenna and G. J. Farrar The Molecular Genetic Approach to Macular Degeneration E. M. Stone and V. C. Sheffield Molecular Genetics of Retinoblastoma J. K. Cowell Color Vision Defects J. Neitz and M. Neitz X-linked Retinitis Pigmentosa M. A. Aldred, M. Jay and A. F. Wright Congenital Stationary Night Blindness: A Critical Review for Molecular Approaches Heon and M. A. Musarella Choroideremia F. P. M. Cremers and H.-H. Ropers Norrie Disease A. A. B. Bergen, W Berger, Z.-Y. Chen, P. J. Diergaarde, E. M. Bleek.er-Wagemak.ers, E. M. Battinelli, M. Warburg, H.-H. Ropers and I. Craig X-linked Juvenile Rednoschisis A. de la Chapelle, T. Alitalo and H. Forsius Clinical and Genetic Heterogeneity of Usher Syndrome W. J. Kimberling, M. Weston and C. Moller VITREOUS/LENS Marfan Syndrome P. Tsipouras and. M. W Kilpatrick Lowe Oculocerebrorenal Syndrome I. Okabe and R. L. Nussbaum Crystallin Genes and Cataract M. Cartier, L.-C. Tsui, S. P. Ball and N. H. Lubsen ANTERIOR SEGMENT Aniridia I. Hanson, T. Jordan and V. van Heyningen METABOLIC Mitochondrial DNA Mutations and the Eye M. D. Brown, M. T. Lott and D. C. Wallace GLOSSARY INDEX

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Author Information

Alan F. Wright, MRC Human Genetics Unit, Western General Hospital Crewe Road, Edinburgh. Barrie Jay, Emeritus Professor of Clinical Ophthalmology, University of London, UK.

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