Overview

This volume offers an overview of the progress in our understanding of the pathogenesis of important bacterial pathogens, and gives an insight into how these advances have been made via uses of recombinant DNA and other molecular techniques. Much of this work came from the laboratory of Dr Stanley Falkow, and all of the contributors to this book are alumni of the Falkow laboratory. Introductory chapters outline the situation when Dr Falkow and his staff first began their investigations, describe key experiments, and give a flavour of the laboratory atmosphere at the time. The 29 chapters following are topical reviews of key areas in what is one of the frontier fields of contemporary microbiology.

Full Product Details

Author:   Virgina L Miller ,  James B Kaper ,  Daniel A Portnoy ,  Ralph R Isberg
Publisher:   American Society for Microbiology
Imprint:   American Society for Microbiology
Dimensions:   Width: 17.80cm , Height: 3.50cm , Length: 25.40cm
Weight:   1.188kg
ISBN:  

9781555810825

ISBN 10:   1555810829
Pages:   566
Publication Date:   10 October 1994
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Unknown
Availability:   Awaiting stock  

Table of Contents

Part 1 Retrospective look at earlier advances: molecular nature, conjugal transfer and replication of extrachromosomal elements 1961 to 1973; R plasmids and antibiotic resistance; transposon Tn3, 1973 to 1980; enterotoxic escherichia coli, 1971 to 1979; molecular epidemiology - development and application of molecular methods to solve infectious disease mysteries. Part 2 Adhesins: adherence mechanisms in urinary tract infections; escherichia coli type 1 pili; mechanisms of pilus antigenic variation in neisseria gonorrhoea; type 4 pili in the families moraxellaceae and neisseriaceae; genes for the filamentous haemagglutinin and fimbriae of bordetella pertussis - co-location, co-regulation and co-operation?; early events in the pathogenesis of haemophilus influenzae disease; molecular pathogenesis of enteropathogenic escherichia coli; murine colonic hyperplasia. Part 3 Molecular and cellular biology of intracellular bacteria: genetic approaches to understanding salmonella pathogenicity; mechanisms of yersinia entry into mammalian cells; cell biology of salmonella pathogenesis; intracellular trafficking of legionella pneumophila within phagocytic cells; cellular biology of listeria monocytogenes infection; determinants of chlamydial pathogenesis and immunity. Part 4 Extracellular structures and products: genetic analysis of the escherichia coli K1 capsule gene cluster; type III capsular polysaccharide of group B streptococci - role in virulence and the molecular basis of capsule expression; unorthodox secretion by gram-negative bacteria; holistic perspective on the escherichia coli haemolysin; YOPS of the pathogenic listeria SPP; role of flagella in campylobacter pathogenesis; molecular biology and role in disease of the vero- (shiga-like) toxins of escherichia coli. Part 5: Virulence gene regulation: co-ordinate regulation of virulence in bordetella pertussis mediated by the vir/bvg locus; methylation-dependent and lrp-dependent fimbrial gene regulation in escherichia coli; the tao of urease; pJM1 plasmid-mediated iron transport-virulence system of vibrio anguillarum. Part 6 Other aspects of bacterial pathogenesis: role of sucrose metabolism in the carcinogenicity of the mutans streptococci; how many bacteria does it take to cause diarrhoea and why?; genetics as a route toward mucosal vaccine development; phylogenetic diversity of microbial pathogens.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions