Overview

The studies in this text provide information on the mechanisms by which viruses have evolved together with their natural hosts by acquiring RNA and DNA molecules from the infected cells into their genomes. Part A is devoted to studies on virus genes that were acquired to evade the vertebrate host immune system. Part B deals with the acquisition of cellular and foreign virus genes by Herpes and Irido viruses. The studies presented in Part C describe the poxvirus genes that are homologues of cellular genes. Together, these studies provide an insight into the evolutionary processes that viruses have developed to control the metabolic machinery of the infected tissue cells, and to prevent the defense machinery of the infected host, for example, the immune system, from recognizing the infecting virus. Such mechanisms may explain the pathogenicity and reflect the virulence of viruses.

Full Product Details

Author:   Yechiel Becker ,  Gholamreza Darai
Publisher:   Springer
Imprint:   Springer
Edition:   Reprinted from VIRUS GENES, 21:1/2, 2001
Weight:   0.647kg
ISBN:  

9780792379034

ISBN 10:   0792379039
Pages:   133
Publication Date:   30 November 2000
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

A: Virus Genes Acquired to Evade the Host Immune Responses.- Evolution of Viruses by Acquisition of Cellular RNA or DNA Nucleotide Sequences and Genes: An Introduction.- Immunomodulatory Functions Encoded by the E3 Transcription Unit of Adenoviruses.- Immune Escape by Hepatitis B Viruses.- MHC Class I-Subversive Gene Functions of Cytomegalovirus and their Regulation by Interferons-an Intricate Balance.- B: Acquisition of Cellular and Viral Genes by Herpes and Iridoviruses.- Marek’s Disease Herpesvirus Transforming Protein MEQ: a c-Jun Analogue with an Alternative Life Style.- Herpesvirus Homologues of Cellular Genes.- Iridovirus Homologues of Cellular Genes—Implications for the Molecular Evolution of Large DNA Viruses.- C: Poxvirus Gene Homologues of Cellular Genes.- Sequence and Functional Analysis of a Homolog of Interleukin-10 Encoded by the Parapoxvirus Orf Virus.- Myxoma Virus Expresses a TNF Receptor Homolog with two Distinct Functions.- Poxvirus Homologues of Cellular Genes.

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