Overview

A diverse collection of readily reproducible methods for use in cancer detection. Highlights include FISH-based methodologies currently used in the diagnosis of solid tumors, the molecular diagnosis of genetic abnormalities by DNA array technologies - including sequence-specific oligonucleotide arrays and CGH arrays - and methodologies directed at the detection of epigenetic events and at quantitative gene expression. The authors apply these novel diagnostic procedures to a broad range of cases taken from cytology, solid tumor pathology, hematology, and rare cell detection, paying special attention to potential future developments and the practical problems of dealing with quality control and accuracy.

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9781588291608

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Reviews

Review of the First Edition The techniques described here are standard laboratory lore;the added value are the notes and tips on tricky details andoften overlooked precautions...Laboratory scientists...will get their money's worth. - Modern Pathology

...concise and uniformly well written...contains a large compilation of applications of nucleic acid technologies that are in use or may be in use in the near future to diagnose and aid in the management of malignant diseases. - Doody's Health Sciences Book Review Journal Review of the First Edition The techniques described here are standard laboratory lore;the added value are the notes and tips on tricky details andoften overlooked precautions...Laboratory scientists...will get their money's worth. -Modern Pathology ...a diverse collection of readily reproducible methods...the protocols presented follow step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. - Tumori From the reviews of the second edition: Dramatic advances in molecular biology over the past decades have led to an unprecedented understanding of cancer at a very detailed molecular level. ... tips on troubleshooting are presented in each chapter, written by experts in the field. Given the amount of detail incorporated in each protocol, these should be readily reproducible and enable laboratories with no prior experience in a specific technique to master it and be able to use todays most powerful techniques in the molecular diagnosis of cancer. (Janis Racevskis, Medical Oncology, Vol. 22 (3), 2004)

...concise and uniformly well written...contains a large compilation of applications of nucleic acid technologies that are in use or may be in use in the near future to diagnose and aid in the management of malignant diseases. - Doody's Health Sciences Book Review JournalReview of the First EditionThe techniques described here are standard laboratory lore;the added value are the notes and tips on tricky details andoften overlooked precautions...Laboratory scientists...will get their money's worth. -Modern Pathology ...a diverse collection of readily reproducible methods...the protocols presented follow step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. - Tumori From the reviews of the second edition: Dramatic advances in molecular biology over the past decades have led to an unprecedented understanding of cancer at a very detailed molecular level. ! tips on troubleshooting are presented in each chapter, written by experts in the field. Given the amount of detail incorporated in each protocol, these should be readily reproducible and enable laboratories with no prior experience in a specific technique to master it and be able to use todays most powerful techniques in the molecular diagnosis of cancer. (Janis Racevskis, Medical Oncology, Vol. 22 (3), 2004)

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