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Author:   Barbara Burtness ,  Erica A. Golemis
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2014
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   5.621kg
ISBN:  

9781493944897

ISBN 10:   1493944894
Pages:   362
Publication Date:   03 September 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Overview: The Pathobiology of Head and Neck Cancer.- Human papillomavirus (HPV)-positive head and neck cancer and the Wnt signaling pathway.- EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer.- The Role of HGF/c-MET in Head and Neck Squamous Cell Carcinoma.- Insulin-like Growth Factor-1 Receptors in Head and Neck Cancer.- The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma.- Jak/STAT Signaling in HNC.- TGFβ regulates EMT in head and neck cancer.- p53 in Head and Neck Cancer.- DNA damage proteins and response to therapy in head and neck cancer.- Hypoxia and radioresistance in head and neck cancer.- The Wnt β-catenin Signaling Circuitry in Head and Neck Cancer.- Sequencing HNC: Emergence of Notch Signaling.- Gene Expression in HNC.- Epidemiology of HPV in Head and Neck Cancer; variant strains, discrete protein function.- Projections: Novel Therapies for HPV-Negative Cancers of the Head and Neck.- Index.

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Author Information

Barbara Burtness, M.D. is Associate Director for Clinical Research at the Fox Chase Cancer Center. She is also a co-leader of the Keystone Program in Head and Neck Cancer. As Chair of the Head and Neck Committee in the Eastern Cooperative Oncology Group and a member of the NCI Head and Neck Steering Committee, she helps shape the national agenda for research on all stages of head and neck cancer. Erica Golemis, Ph.D. is the Deputy Chief Scientific Officer at the Fox Chase Cancer Center. She is also the Co-Leader of Developmental Therapeutics and Co-Leader of the Head and Neck Cancer Keystone at Fox Chase. Her research seeks to define the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes.

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