Overview

The unraveling of the biology and disease mechanisms of the parathyroid has taken great strides in the recent few years. Parathyroid molecular biology is the first book to describe recent studies and discoveries in the field in detail. Key topics addressed include: The study of the molecular biology of the parathyroid hormone gene and its regulation by calcium, phosphate, and vitamin D The generation of mice with genetic deletions of the parathyroid, as well as mice which fail to develop the parathyroid gland The parathyroid's connection to the calcium receptor and its effects, such as regulation of PTH secretion, gene expression, and proliferation The genetic mutations leading to diseases of decreased or excessive activity of the parathyroid The mechanisms of actions associated with patients with chronic renal failure and the development of markedly excessive activity of the parathyroid that causes severe bone disease This book will be essential reading to everyone interested in the latest developments in this burgeoning field.

Full Product Details

Author:   Tally Naveh-Many
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2005
Dimensions:   Width: 15.60cm , Height: 1.10cm , Length: 23.40cm
Weight:   0.336kg
ISBN:  

9781441934154

ISBN 10:   1441934154
Pages:   199
Publication Date:   06 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Development of Parathyroid Glands.- Parathyroid Hormone, from Gene to Protein.- Toward an Understanding of Human Parathyroid Hormone Structure and Function.- The Calcium Sensing Receptor.- Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate.- In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene.- Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D.- Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure.- Parathyroid Gland Hyperplasia in Renal Failure.- Molecular Mechanisms in Parathyroid Tumorigenesis.- Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism.- Genetic Causes of Hypoparathyroidism.- Skeletal and Reproductive Abnormalities in Pth-Null Mice.

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