Overview

This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro­ priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis­ tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl­ edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.

Full Product Details

Author:   Beatrice Singer ,  D. Grunberger
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1983
Dimensions:   Width: 17.00cm , Height: 1.90cm , Length: 24.40cm
Weight:   0.628kg
ISBN:  

9781461337744

ISBN 10:   1461337747
Pages:   348
Publication Date:   12 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

I Introduction.- II Chemicals as Environmental Mutagens and Carcinogens.- III Intrinsic Properties of Nucleic Acids.- A. Introduction 15.- B. Reactions with Water.- C. Reversible Equilibrium Reactions.- D. Fidelity in Nucleic Acid Synthesis.- E. Transcription and Replication of Modified Templates.- IV Reactions of Directly Acting Agents with Nucleic Acids.- A. Introduction.- B. Simple Nonalkylating Agents.- C. Monofunctional Alkylating Agents.- D. Bifunctional Alkylating Agents.- E. Cyclic Alkylating Agents.- F. Vinyl Halides.- G. Alkyl Carbamates.- V Metabolic Activation of Carcinogens and Mutagens.- A. Enzymatic Activation of Polycyclic Aromatic Hydrocarbons.- B. Specific Metabolites of Polycyclic Aromatic Hydrocarbons.- C. Enzymatic Activation of N-Substituted Aromatic Compounds and Resulting Metabolites.- D. Summary.- VI Reactions of Metabolically Activated Carcinogens with Nucleic Aclds.- A. Detection of DNA-Carcinogen Adducts.- B. Polycyclic Aromatic Hydrocarbons.- C. N-Substituted Aromatic Compounds.- D. Naturally Occurring Carcinogens.- VII Conformation of DNA Modified by Bulky Aromatic Carcinogens.- A. Introduction.- B. Methods of Analysis.- C. Conformation of DNA-7,8-Dihydrodiol-9,lO-Oxide-Benzo[a]pyrene Adducts.- D. Conformation of DNA Modified by N-Substituted Aromatic Compounds.- VIII Repair in Mammalian Organs and Cells.- A. Introduction.- B. In Vivo Removal of Alkyl Derivatives.- C. Mechanisms of Repair of Alkyl Derivatives in Eukaryotes.- D. In Vivo Removal of Aromatic Derivatives.- IX Site-Directed Mutagenesis.- Appendix A UV Spectral Characteristics and Acidic Dissociation Constants of Modified Bases, Nucleosides, and Nucleotides.- Appendix B Acid, Neutral, and Basic Spectra of Bases, Nucleosides, Nucleotides, and 55 Modified Derivatives.

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