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OverviewThyroid cancer is the fastest growing cancer in the U.S., especially among women. Given the relative success we have had in its treatment, there is a need to capitalize on it by better understanding the factors that underpin this malignancy, and exploring better strategies for diagnosis, treatment, and follow-up. To do so, we must take full advantage of the revolution in modern biology. This comprehensive volume addresses the needs of a broad readership. Against a backdrop of the complexity of the origins of cancer, pathology of thyroid tumors, including lymphomas, is discussed, as are molecular genetic lesions associated with spontaneous and radiation-related thyroid tumors, diagnostic tests available to surmise tumor subtypes (including a review of the potential of DNA micro arrays), advances in therapeutics (including recombinant hTSH superagonists, allowing for better treatment of well differentiated thyroid carcinoma and its imaging), and combinations of drugs that might influence the course of poorly differentiated and anaplastic thyroid cancer. In this book, we glimpse into the promise of gene therapy in the future management of otherwise lethal anaplastic and poorly differentiated thyroid tumors. The molecular genetics of medullary thyroid cancer is considered in depth, and malignancy is used as a showcase for genetic prediction and counseling. Full Product DetailsAuthor: NADIR R. FARIDPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: Softcover reprint of hardcover 1st ed. 2004 Volume: 122 Dimensions: Width: 15.50cm , Height: 2.30cm , Length: 23.50cm Weight: 0.769kg ISBN: 9781441954763ISBN 10: 1441954767 Pages: 444 Publication Date: 16 December 2010 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Out of stock ![]() The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsThe Origin of Cancer.- The Pathology of Thyroid Cancer.- Thyroid Lymphomas.- Molecular Events in Follicular Thyroid Tumors.- Molecular Epidemiology of Thyroid Cancer.- Growth Factors and their Receptors in the Genesis and Treatment of Thyroid Cancer.- Biology of Ras in Thyroid Cells.- P53 and other Cell Cycle Regulators.- Abnormalities of Nuclear Receptors in Thyroid Cancer.- Matrix Metalloproteinases in Thyroid Cancer.- The Molecular Pathways Induced by Radiation and Leading to Thyroid Carcinogenesis.- TRK Oncogenes in Papillary Thyroid Carcinoma.- Thyroidal Iodide Transport and Thyroid Cancer.- Molecular Signaling in Thyroid Cancer.- Gene Expression in Thyroid Tumors.- Animal Models of Thyroid Carcinogenesis.- Diagnostic Molecular Markers in Thyroid Cancer.- Thyroid Cancer Imaging.- Past, Presence and Future of Thyroid-Stimulating Hormone (TSH) Superactive Analogs.- Pathobiology of Antineoplastic Therapy in Undifferentiated Thyroid Cancer.- Gene Therapy for Thyroid Cancer.- Familial Papillary Thyroid Carcinoma.- Ret Activation in Medullary Carcinomas.- From Genes to Decisions.ReviewsDoody Enterprises, Inc., 500 N. Michigan Ave. Suite 1410, Chicago, IL 60611, Tel:312-644-7640, anne@doody.com Reviewer's Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center) This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much. Doody Enterprises, Inc., 500 N. Michigan Ave. Suite 1410, Chicago, IL 60611, Tel:312-644-7640, anne@doody.com Reviewer's Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center) This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much. Doody Enterprises, Inc., 500 N. Michigan Ave. Suite 1410, Chicago, IL 60611, Tel:312-644-7640, anne@doody.com Reviewer's Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center) This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much. Author InformationTab Content 6Author Website:Countries AvailableAll regions |