Overview

How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.

Full Product Details

Author:   Hinrich Gronemeyer ,  Ulrike Fuhrmann ,  Karsten Parczyk
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   24
Dimensions:   Width: 14.80cm , Height: 1.30cm , Length: 21.00cm
Weight:   0.339kg
ISBN:  

9783662036914

ISBN 10:   3662036916
Pages:   238
Publication Date:   03 October 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Nuclear Receptors as Targets for Drug Design: New Options and Old Challenges.- 2 The Androgen Receptor Co-regulator, ARA70.- 3 Role of Coactivators in Transcriptional Activation by Estrogen Receptors.- 4 A Search for a Mechanism for the Antiinflammatory Action of Glucocorticoids.- 5 Activation of Progesterone and Androgen Receptors by Signal Transduction Pathways.- 6 Ligand-Independent Activation of the Estrogen Receptor: Activation by Epidermal Growth Factor and Dopamine.- 7 The ER/AP1 Pathway: A Window on the Cell-Specific Estrogen-like Effects of Antiestrogens.- 8 A Structural View of the Retinoid Nuclear Receptors.- 9 Characterization of Human Estrogen Receptorß.- 10 Functional and Pharmacological Analysis of the A and B Forms of the Human Progesterone Receptor.- 11 Oestrogen Receptor Expression Mutants and Variants in Tamoxifen-Resistant Breast Cancer.- 12 Structure and Expression of the Androgen Receptor in Prostate Cancer.- Previous Volumes Published in this Series.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions