Overview

This book bridges the gap between life sciences and physical sciences by providing several perspectives on cellular and molecular mechanics on a fundamental level. It begins with a general introduction to the scales and terms that are used in the field of cellular and molecular biomechanics and then moves from the molecular scale to the tissue scale. It discusses various tissues or cellular systems through the chapters written by prominent engineers and physicists working in various fields of biomechanics. Big picture items, such as the number of atoms in cells and the number of cells in an organism, are discussed, followed by several of the physical laws that play a central role in nanoscale biomechanics, including the mechanics of the nucleus and its associated molecules. The book provides several case studies in atomic force microscopy and examines the physical relationship between living cells and laboratory substrata. It delves deeply into the molecular mechanisms of axonal growth, transport, and repair and provides a mechanistic framework for understanding the underlying molecular conditions that contribute to heart disease. While the quantitative and straightforward language of the book will help the engineering community grasp the concepts better and utilize them effectively, the questions given in each chapter will encourage upper-level undergraduate students, graduate students, or those generally interested in understanding cellular and molecular mechanics to dig deeper into the material. The complimentary solutions manual is available for qualified instructors upon request.

Full Product Details

Author:   Bradley Layton
Publisher:   Pan Stanford Publishing Pte Ltd
Imprint:   Pan Stanford Publishing Pte Ltd
ISBN:  

9789814613446

ISBN 10:   9814613444
Pages:   232
Publication Date:   25 March 2015
Audience:   General/trade ,  College/higher education ,  General ,  Tertiary & Higher Education
Format:   Electronic book text
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Introduction Brief overview of numbers and scales History of cell mechanics Outline of the book Problems Mechanics of Single Molecules and Single Proteins Macromolecules, small molecules, and machines: How are they alike? How do they differ? Thermal energy, equipartition, and the Boltzmann distribution Thermal ratchets: what are they? A practical definition Detailed balance Entropy and enthalpy Two ways to model a chemomechanical transition: macromechanical view versus statistical mechanics view - when do they apply? Conclusions Problems Nucleus Mechanics DNA Lamins Whole nucleus properties Problems Nanoscale Imaging and Modeling The structures of entropy partitioning Atomic force microscopy Further Considerations Questions Cell-substrate Interactions Introduction Effect of substrate stiffness and matrix ligand on cell morphology Morphology: Integration of biochemical and biophysical factors Effect of substrate stiffness and matrix ligand on cell motility Motility: Integration of biochemical and biophysical factors Effect of substrate stiffness and matrix ligand on cell mechanics Cell mechanics: Integration of biochemical and biophysical factors Changes in substrate stiffness in disease Cell-Substrate Mechanics: Conclusions Axonal Transport and Neuromechanics Introduction Structural organization within the neuron Axonal Transport of the Cytoskeleton Neuromechanics Summary and Outlook Implications for Disease - Valvular Fibrosis and the Myofibroblast Introduction The Myofibroblast Mechanical Regulation of Valvular Fibrosis Conclusions Index References

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Author Information

Bradley E. Layton is associate professor in the Applied Computing and Engineering Technology Department and an affiliated faculty in the Biophysics and Biochemistry Program at the University of Montana, USA. He earned his PhD in biomedical engineering and MS in mechanical engineering at the University of Michigan, USA. He also holds an SB in mechanical engineering from the Massachusetts Institute of Technology, USA, and a Professional Engineer's license. Prof. Layton is an editor for the Institute of Electrical Engineering and Electronics and Engineering in Medicine and Biology Society, and a member of the American Society of Mechanical Engineering and the Order of the Engineer. He is an avid bicycle builder, cyclist, kayaker, and a former member of the United States National Rowing Team. He lives with his wife and two children in the Rattlesnake Valley in Missoula, Montana.

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