Overview

The rapid developments in molecular biology have been applied to a wide range to biological and medical disciplines. Their application to the mechanisms, development, control and treatment of sexually transmitted diseases is addressed in this volume, the first in the ""Molecular and Cell Biology of Human Diseases"" series. The book reviews the status of research on a range of sexually transmitted diseases whose incidence has paralleled the increase in HIV infection and examines the ways in which new methods are influencing current practice and are likely to shape future management. As diagnosis, control and treatment of sexually transmitted diseases is increasing worldwide, this book is timely in providing an assessment of current research and its practical and clinical implications. Written by an international team of experts, it is a reference source both for biomedical researchers and clinicians. This book should be of interest to researchers and graduate students in medical microbiology, clinical biochemistry, molecular medicine, venereal diseases, infectious diseases and dermatology and clinicians in similar areas.

Full Product Details

Author:   D.J. Wright ,  L.C. Archard
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   1992 ed.
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   1.450kg
ISBN:  

9780412365102

ISBN 10:   0412365103
Pages:   318
Publication Date:   30 September 1992
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Molecular mechanisms of antigenic variation in Neisseria gonotthoeae.- 1.1 Introduction.- 1.2 Gonococcal pathogenesis.- 1.3 Diagnosis and treatment of gonorrhoea.- 1.4 The surface of N. gonorrhoeae.- 1.5 Immune responses in gonorrhoea.- 1.6 Mechanisms of antigenic variation.- 1.7 Pili.- 1.8 Protein II.- 1.9 Conclusions.- References.- 2 Molecular biology of chlamydiae.- 2.1 Chlamydiae and human diseases.- 2.2 Chlamydial life cycle.- 2.3 Chlamydial chromosome.- 2.4 Chromosomal genes and products.- 2.5 Chlamydial antigens.- 2.6 Plasmid.- 2.7 DNA probes for the detection of chlamydiae.- 2.8 Chlamydial nucleic acids in tissue culture.- 2.9 Chlamydial nucleic acids in specimens.- 2.10 Amplified chlamydial nucleic acids.- 2.11 The story to date.- Acknowledgements.- References.- 3 Sexually transmitted mycoplasmas in humans.- 3.1 Classification.- 3.2 Sexually transmitted human species of mycoplasmas.- 3.3 Diseases associated with M. genitalium.- 3.4 Diseases associated with M. fermentans.- 3.5 Diseases associated with M. hominis.- 3.6 Diseases associated with U. urealyticum.- 3.7 Cell biology of mollicutes.- 3.8 Distinguishing properties of the genera and species.- 3.9 Molecular biology of mycoplasmas.- 3.10 Nucleic acid and immunological probes for detecting pathogenic mycoplasmas.- 3.11 Pathogenic, disease-related and immunogenic components of mycoplasmas.- 3.12 Pathogenic mechanisms of M. genitalium.- 3.13 Pathogenic mechanisms of M. fermentans.- 3.14 Pathogenic mechanisms of M. hominis.- 3.15 Pathogenic mechanisms of U. urealyticum.- References.- 4 Molecular biology of Treponema palIidum.- 4.1 Syphilis.- 4.2 The cell envelope of T. pallidum.- 4.3 The T. pallidum genome and molecular cloning of genes.- 4.4 Treponema pallidum lipoproteins.- 4.5 Glycosylation.- 4.6 The endoflagellum.- 4.7 The heat-modifiable oligomeric 4D antigen.- 4.8 Translational and transcriptional signals.- 4.9 Recombinant technology in the diagnosis of syphilis.- 4.10 Pathogenesis of T. pallidum.- 4.11 The surface of T. pallidum and immunity.- 4.12 The central paradox.- 4.13 Antigenic variation.- 4.14 Vaccines against syphilis.- Acknowledgements.- References.- 5 Molecular biology of Candida pathogenesis.- 5.1 Introduction.- 5.2 Growth of Candida as it relates to pathogenesis.- 5.3 The biology of dimorphism as it relates to pathogenesis.- 5.4 High frequency switching as it relates to pathogenesis.- 5.5 Genotypic variability as it might relate to pathogenesis.- 5.6 Other phenotypic traits as they relate to pathogenesis.- 5.7 The application of molecular genetic tools to questions of Candida etiology and epidemiology.- 5.8 The basic questions which remain unanswered and why.- 5.9 The range of methods used to assess genetic relatedness between Candida strains.- 5.10 Preliminary answers to epidemiological and etiological questions using DNA fingerprinting.- 5.11 Discussion.- Acknowledgement.- References.- 6 Molecular analysis of Trichomonas vaginalis surface protein repertoires.- 6.1 Introduction.- 6.2 Antigenic diversity and the immunogen repertoires.- 6.3 The double-stranded RNA virus of T. vaginalis.- 6.4 Batch versus chemostat grown trichomonads and antigenic diversity.- 6.5 Cytoadherence and the trichomonad adhesin repertoire.- 6.6 The nutrient acquisition protein repertoires.- 6.7 Conclusions.- References.- 7 Hepatitis B virus and hepatitis delta virus.- 7.1 Introduction.- 7.2 Biology of hepatitis B virus.- 7.3 Epidemiology and transmission of hepatitis B.- 7.4 Acute hepatitis B.- 7.5 Chronic hepatitis B.- 7.6 Treatment.- 7.7 Prevention.- 7.8 New hepatitis B vaccines.- 7.9 Hepatitis delta virus (HDV).- References.- 8 Molluscum contagiosum virus.- 8.1 Introduction.- 8.2 Clinical features.- 8.3 Pathology.- 8.4 Immunology.- 8.5 Transmission and epidemiology.- 8.6 Virion structure and life cycle.- 8.7 Attempts at virus propagation.- 8.8 Genome structure and organization.- 8.9 Molluscum contagiosum virus subtype nomenclature.- 8.10 Molecular epidemiology.- 8.11 Possible mechanisms of MCV-induced tumourigenesis.- 8.12 The Molluscum contagiosum virus homologue of the vaccinia virus major envelope protein: control of MCV gene expression.- References.- 9 Molecular biology of herpes simplex virus.- 9.1 Introduction.- 9.2 Taxonomy.- 9.3 The herpes virus virion.- 9.4 The viral genome.- 9.5 Productive infection.- 9.6 Latency.- 9.7 Virulence.- 9.8 Antiviral agents.- 9.9 Immunization against infection.- 9.10 Detection of HSV.- References.- 10 Anti-idiotypic therapeutic strategies in HIV infection.- 10.1 Introduction — the CD4/gp120 interaction.- 10.2 The CD4 molecule — structure and function.- 10.3 gp120 — structure and function.- 10.4 Homology of gp120 with members of the immunoglobulin supergene family (IgSF).- 10.5 Immunosuppressive effects of gp120 in vitro.- 10.6 The anti-idiotype strategy.- 10.7 Epitope mapping of CD4.- 10.8 Conclusions.- References.

Reviews

'... a collection of excellent reviews... a valuable source of information to potential research workers as well as a useful reference for those currently involved in research into sexually transmitted diseases.' Journal of Medical Microbiology

... a collection of excellent reviews... a valuable source of information to potential research workers as well as a useful reference for those currently involved in research into sexually transmitted diseases.' Journal of Medical Microbiology

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