Overview
Modern Synthetic Methodologies Toward Glycomimetics contains 10 chapters describing the syntheses of natural and non-natural glycomimetics using modern transition metal catalyzed reactions. This book also contains several experimental details allowing the readers to get familiar with such intricate reactions using complex alkylidene carbenoids, samarium diodide, dicobalt octacarbonyl alkyne cyclotrimerization, and the like. The descriptions of biologically active carbohydrates are elegantly detailed. A new solution-phase glycopeptide synthesis using unprotected glycosyl amino acids as phase-tags is also described. Important strategies into the design of complex sialic acid C-saccharides, aryl C-glycosides, and conformationally restricted analogs of the important sialyl Lewis X are discussed. Tethering of carbohydrate residues through ester bonds and applications of the Tebbe's methylenation and either ring closing metathesis or intramolecular C-glycosidations are used to provide novel carbohydrate analogs.
Full Product Details
Author: René Roy (Professor of Chemistry, Professor of Chemistry, Université du Québec à Montréal)
Publisher: Oxford University Press Inc
Imprint: Oxford University Press Inc
Volume: No. 896
Dimensions:
Width: 15.80cm
, Height: 1.50cm
, Length: 23.60cm
Weight: 0.365kg
ISBN: 9780841238800
ISBN 10: 0841238804
Pages: 202
Publication Date: 03 March 2005
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: No Longer Our Product
Availability: Out of stock 
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.
Table of Contents
Preface 1: Alois Furstner: Reflections upon Olefin Metathesis in Carbohydrate Chemistry 2: Maarten H.D. Postema, Jared L. Piper, Lei Liu, Venu Komanduri, and Russell L. Betts: Synthesis of Stable Carbohydrate Mimetics 3: Chi-Chang Chen, Dino Ress, and Robert J. Linhart: Synthesis of Neu5Ac, KDN, and KDO C-Glycosides 4: Emma R. Palmacci, Holger Herzner, and Peter H. Seeberger: Synthesis of C-Glycosides with Glycosyl Phosphates 5: Kathlyn A. Parker: Aryl C-Glycosides by the Reverse Polarity Approach 6: Peter S. Belica, Alain Berthold, Nikki Charles, Guangwu Chen, Ajit Parhi, Paolo Pasetto, Jun Pu, Guangli Yang, and Richard W. Franck: The Ramberg-Backlund Way to C-Glyucosides 7: R.W. Denton, and D.R. Mootoo: Conformationally Restrained C-Glycoside Probes for Sialyl Lewis X-Selectin Recognition 8: Rene Roy, M. Corazon Trono, and Denis Giguere: Effects of Linker Rigidity and Orientation of Mannoside Clusters for Multivalent Interactions with Proteins 9: Vincent Bouvet, and Robert N. Ben: Antifreeze Glycoprotein Analogs: Synthesis, In Vitro Testing, and Applications 10: Zhongwu Guo: Unprotected Oligosaccharides as Phase Tags for Solution-Phase Glycoprotein Synthesis with Solid-Phrase Workup Author Index Subject Index
Reviews
The book provides outstanding chapters by a highly recognised group of researchers that will serve as a valuable tool for well-trained traditional glycochemists and particularly for newcomers in the field of glycomimetics. Current Engineering Practice, Volume 48 2005.
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