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Author:   Julio Alvarez-Builla (Departamento de Quimica Organica, Universidad de Alcala, Madrid, Spain) ,  Juan Jose Vaquero (Universidad de Alcala, Alcala de Henares (Madrid), Spain) ,  José Barluenga (Instituto Universitario de Quimica Organometalica, Universidad de Oviedo, Oviedo, Spain)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
Edition:   4 Volume Set
Dimensions:   Width: 23.90cm , Height: 17.80cm , Length: 30.00cm
Weight:   5.647kg
ISBN:  

9783527332014

ISBN 10:   3527332014
Pages:   2530
Publication Date:   29 June 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Volume One HETEROCYCLIC COMPOUNDS: AN INTRODUCTION Heterocyclic Compounds: An Introduction Structure and Reactivity of Aromatic Five-Membered Systems Structure and Reactivity of Aromatic Six-Membered Systems Basic Literature on Heterocyclic Compounds THREE-MEMBERED HETEROCYCLES: STRUCTURE AND REACTIVITY Aziridines 2H-Azirines Oxiranes Thiiranes Diaziridines 3H-Diazirines Oxaziridines Dioxiranes FOUR-MEMBERED HETEROCYCLES: STRUCTURE AND REACTIVITY Azetidines Oxetanes Thietanes Other Four-Membered Heterocycles FIVE-MEMBERED HETEROCYCLES: PYRROLE AND RELATED SYSTEMS Introduction General Reactivity Relevant Natural and/or Useful Compounds Pyrrole Ring Synthesis Reactivity Pyrrole Derivatives Addendum FIVE-MEMBERED HETEROCYCLES: INDOLE AND RELATED SYSTEMS Introduction General Properties Relevant Natural and/or Useful Compounds Indole Synthesis Reactivity of Indole Chemistry of Indole Derivatives Addendum FIVE-MEMBERED HETEROCYCLES: FURAN Introduction Synthesis of Furans Reactivity Oxyfurans and Aminofurans Addendum FIVE-MEMBERED HETEROCYCLES: BENZOFURAN AND RELATED SYSTEMS Introduction General Structure and Reactivity Isolation of Naturally Occurring Benzofurans Synthesis of Benzofuran Uses of Benzofuran Volume Two FIVE-MEMBERED HETEROCYCLES: 1,2-AZOLES. PART 1. PYRAZOLES Introduction General Reactivity Relevant Natural and/or Useful Compounds Synthesis of Pyrazoles and Indazoles Reactivity Derivatives FIVE-MEMBERED HETEROCYCLES: 1,2-AZOLES. PART 2. ISOXAZOLES Introduction General Reactivity Relevant Natural and/or Useful Compounds Synthesis of Isoxazoles and Isothiazoles Synthesis of Benzisoxazoles and Benzisothiazoles Reactivity of 1,2-Azoles FIVE-MEMBERED HETEROCYCLES: 1,2-AZOLES Introduction General Reactivity Synthesis of Aromatic 1,3-Azoles Reactivity Derivatives FIVE-MEMBERED HETEROCYCLES WITH TWO HETEROATOMS: O AND S DERIVATIVES Introduction 1,2-Dioxoles and 1,2-Dioxolanes 1,3-Dioxoles and 1,3-Dioxolanes 1,2-Dithioles and 1,2-Dithiolanes 1,3-Dithioles and 1,3-Dithiolanes 1,2-Oxathioles and 1,2-Oxathiolanes 1,3-Oxathioles and 1,3-Oxathiolanes FIVE-MEMBERED HETEROCYCLES WITH THREE HETEROATOMS: TRIAZOLES 1,2,3-Triazoles Benzotriazole 1,2,4-Triazoles OXADIAZOLES Introduction 1,2,3-Oxadiazoles 1,2,4-Oxadiazoles 1,2,5-Oxadiazoles 1,3,4-Oxadiazoles Volume Three THIADIAZOLES Introduction 1,2,3-Thiadiazoles 1,2,4-Thiadiazoles 1,3,4-Thiadiazoles FIVE-MEMBERED HETEROCYLCES WITH FOUR HETEROATOMS: TETRAZOLES Introduction Synthetic Methods Reactions of Tetrazoles SIX-MEMBERED HETEROCYCLES: PYRIDINES Introduction Synthesis of Pyridines Reactivity Pyridine Derivatives Appendix SIX-MEMBERED HETEROCYCLES: QUINOLINE AND ISOQUINOLINE Quinoline Isoquinoline SIX-MEMBERED RINGS WITH ONE OXYGEN: PYRYLIUM ION, RELATED SYSTEMS AND BENZO-DERIVATIVES Introduction Pyrylium Cation and Benzo-Derivatives 2H-Pyrans and 4H-Pyrans Pyrones, Coumarins, and Chromones SIX-MEMBERED HETEROCYCLES: 1,2-, 1,3-, AND 1,4-DIAZINES Introduction General Reactivity Relevant Natural/Biological Compounds Synthesis of Pyridazines (1,2-Diazines) Synthesis of Pyrimidines (1,3-Diazines) Synthesis of Pyrazines (1,4-Diazines) Reactivity of Diazines Important Derivatives SIX-MEMBERED HETEROCYCLES: TRIAZINES, TETRAZINES AND OTHER POLYAZA SYSTEMS Introduction 1,2,3-Triazines 1,2,4-Triazines 1,3,5-Triazines Tetrazines Volume Four SEVEN-MEMBERED HETEROCYCLES: AZEPINES, BENZO DERIVATIVES AND RELATED SYSTEMS Introduction Relevant Natural and Useful Compounds Relevated Computational Chemistry, Physicochemical, and Spectroscopic Data Valence Tautomerism in Seven-Membered Heterocycles Synthesis Reactivity of Azepines Reactivity of Oxepines Reactivity of Thiepines HETEROCYCLES CONTAINING A RING-JUNCTION NITROGEN Introduction Pyrrolizines Indolizines Quinolizinium Salts PHOSPHORUS HETEROCYCLES Introduction Phospholes Phosphinines Other P Heterocycles Applications of Phosphorus Heterocycles Addendum THE CHEMISTRY OF 2-AZETIDINONES (BETA-LACTAMS) Monocyclic Derivatives Penicillins and Cephalosporins THE CHEMISTRY OF BENZODIAZEPINES Introduction Relevant Benzodiazepines 1,4-Benzodiazepines: General Synthetic Methods Modifications of the 1,4-Benzodiazepine Ring 1,4-Benzodiazepines with a Fused Heterocycle Pyrrolo[2,1-c][1,4]Benzodiazepines (PBDs) 1,5-Benzodiazepines 2,3-Benzodiazepines PORPHYRINS: SYNTHESES AND REACTIONS Introduction Synthetic Chemistry of Porphyrins and Expanded Porphyrins Reactivity of Porphyrins NEW MATERIALS DERIVED FROM HETEROCYCLIC SYSTEMS Introduction Color and Fluorescent Agents Self-Assembling Materials and Molecular Containers Unnatural Enzyme Models Organic Conductors SOLID PHASE AND COMBINATORIAL CHEMISTRY IN THE HETEROCYCLIC FIELD Introduction Solid Supports Linkers for Solid-Phase Organic Synthesis Heterocyclic Synthesis on Solid-Phase

Reviews

For organic and medical chemists involved with heterocycles - and this means academics and industry professionals working with vitamins, hormones, antibiotics, pharmaceuticals, dyes, and many other products - this reference constitutes an indispensable comprehensive reference. (Book News, 1 October 2011)

?This resource will primarily interest researchers in the field. Summing Up: Recommended. Only comprehensive chemistry collections serving upper-division undergraduates and above.? (Choice, 1 April 2012) For organic and medical chemists involved with heterocycles - and this means academics and industry professionals working with vitamins, hormones, antibiotics, pharmaceuticals, dyes, and many other products - this reference constitutes an indispensable comprehensive reference. (Book News, 1 October 2011)

For organic and medical chemists involved with heterocycles - and this means academics and industry professionals working with vitamins, hormones, antibiotics, pharmaceuticals, dyes, and many other products - this reference constitutes an indispensable comprehensive reference. (Book News, 1 October 2011)<p>

<p> This resource will primarily interest researchers in thefield. Summing Up: Recommended. Only comprehensivechemistry collections serving upper-division undergraduates andabove. (Choice, 1 April 2012) <p> For organic and medical chemists involved with heterocycles -and this means academics and industry professionals working withvitamins, hormones, antibiotics, pharmaceuticals, dyes, and manyother products - this reference constitutes an indispensablecomprehensive reference. (Book News, 1 October 2011) <p>

Author Information

"Julio Alvarez-Builla received his PhD at the University Complutense and spent a postdoc stage with Professor A.R. Katritzky at the University of East Anglia. At present he is full professor of Organic Chemistry at the Faculty of Pharmacy of the University of Alcalá. He has strong interests in collaborating with Pharmaceutical industry, and in relation with that he has been the scientific director of the University's fine chemicals pilot plant facility from 1998 to 2008. His research interests include the chemistry of azinium N-ylides and N-aminides, the chemistry of nitrogen bridgehead heterocycles, and the synthesis of heterocyclic pharmaceutical products. Juan J. Vaquero received his degree in Chemistry from the Complutense University (Madrid) and the PhD degree in Organic Chemistry from the University of Alcalá. He was a NATO postdoctoral fellow with Professor Charles W. Rees at the Imperial College (London). In 1987, he joined the Department of Organic Chemistry of the University of Alcalá where he is a Full Professor Organic Chemistry. He acted as the Dean of the Faculty of Chemistry (2000-2006). His research interests include the chemistry of azonia heterocyclic systems, the synthesis of bioactive compounds targeting DNA and the total synthesis of natural alkaloids. José Barluenga holds the chair of Organic Chemistry at the University of Oviedo, where he founded the Instituto Universitario de Química Organometálica ""Enrique Moles"" and is currently developing his research. During his career, Professor Barluenga has published more than 615 research articles and he has been the recipient of many awards including the Research Award of the ""Alexander von Humboldt"" Foundation, FRG (1989, First Edition), the Solvay Award from Spanish CEOE (1990), the 1st Spain Dupont Award, the Iberdrola Award for Science and Technology (1996), the Gold Medal from the Spanish Society of Chemistry (1999), the ""Enrique Moles"" National Award of Chemical Science and Technology from the Ministry of Education and Science (2001, First Edition) and the Rey Jaime I Award for Basic Research (2005)."

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