Overview

Effectively Assess Intervention Options for Controlling Infectious Diseases Our experiences with the human immunodeficiency virus (HIV), severe acute respiratory syndrome (SARS), and Ebola virus disease (EVD) remind us of the continuing need to be vigilant against the emergence of new infectious diseases. Mathematical modeling is increasingly used in the management of infectious disease control as a way to assess interventions relatively quickly, cheaply, and safely. Modeling to Inform Infectious Disease Control shows readers how to take advantage of these models when developing strategies to mitigate infectious disease transmission. The book presents a way of modeling as well as modeling results that help to guide the effective management of infectious disease transmission and outbreak response. It discusses the requirements for preventing epidemics and ways to quantify the impact of preventative public health interventions on the size and dynamics of an epidemic. The book also illustrates how data are used to inform model choice. Accessible to readers with diverse backgrounds, this book explains how to gain insight into the management of infectious diseases through statistical modeling. With end-of-chapter exercises and glossaries of infectious disease terminology and notation, the text is suitable for a graduate-level public health course. Supplementary technical material is provided at the end of each chapter for readers with a stronger background in mathematics and an interest in the art of modeling. In addition, bibliographic notes point readers to literature in which extensions and more general results can be found.

Full Product Details

Author:   Niels G. Becker
Publisher:   Taylor & Francis Ebooks
Imprint:   Chapman & Hall/CRC
ISBN:  

9781498731072

ISBN 10:   1498731074
Pages:   208
Publication Date:   17 April 2015
Audience:   General/trade ,  College/higher education ,  General ,  Tertiary & Higher Education
Format:   Electronic book text
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Introduction Motivation Terminology Scope and layout of the book Minor outbreaks when infectives are homogeneous When are outbreaks certain to be minor? Preventing epidemics by mass immunization Reproduction number What is a minor outbreak? Probability of a minor outbreak Importation of the infectious disease Estimating R Minor outbreaks in a community of households Modified allocation of offspring Household reproduction number When are outbreaks certain to be minor? Mass immunization Are results affected by the way the infection is imported? Estimating RH Minor outbreaks when individuals differ Type-specific offspring distributions When are outbreaks certain to be minor? Mass immunization Types of individual in a community of households Two reproduction numbers for a community of households Transmission intensity function Describing transmission intensity by a function Estimating the transmission intensity function Role of the transmission intensity function in modeling Partially effective vaccines Vaccine effect on transmission between individuals Impact of mass immunization on the reproduction number Estimating vaccine effects Social distancing What is social distancing? Reduced mixing Isolating symptomatic infectives Targeting high transmission intensities Reducing epidemic size Simulated epidemics The nature of our deterministic epidemic model Epidemic size in a homogeneous community Mass immunization Herd immunity Estimating the reproduction number Types of individual Dynamics of infection incidence The epidemic curve Estimating parameter values from daily incidence data Endemic transmission Using data to inform model choice Model-free comparison of data on outbreak size Transmission among homogeneous individuals Allowing transmission rates to differ between individuals Terminology and notation References Subject index Discussion, Exercises, Supplementary material, and Bibliographic notes appear at the end of each chapter.

Reviews

This new book seeks to fill an important gap in the literature on infectious disease modeling, namely separating the now well-developed mathematical and statistical theory of infectious diseases from its public health application to infectious disease control. Professor Becker bridges the two worlds by presenting a logical succession of simple models that relate to some of the pressing questions arising in outbreak control. The approach is very effective and has resulted in an engaging volume that, in my estimation, will become a classic of the literature and thus a worthy successor to the author's earlier landmark volume on the subject. It will be essential reading for a broad range of scientists working on infectious diseases, notably statisticians, modelers, and epidemiologists with an interest in quantitative methods. -Paddy Farrington, The Open University, UK

Author Information

Niels G. Becker is an emeritus professor of biostatistics at the Australian National University, where he was the director of the National Centre for Epidemiology and Population Health from 2007 until 2011. Dr. Becker has published more than 150 peer-reviewed articles. His research interests include the control of infectious diseases, triggers of adverse health events, and the analysis of foodborne disease data.

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