Overview

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume I guides readers through chapters on QSAR models, DQAsomes, synthesis of Triphenylphosphonium Phospholipid Conjugates, testing of novel isomeric mitochondriotropic derivatives, mTRIP, mitochondria-targeted imaging nanoplatforms, live-cell assessment, mitochondrial coenzyme Q10, rat liver Mitochondrial Lipidome, and Mito-SinCe2. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 1: Targeting Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Full Product Details

Author:   Volkmar Weissig ,  Marvin Edeas
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2nd ed. 2021
Volume:   2275
Weight:   0.898kg
ISBN:  

9781071612644

ISBN 10:   1071612646
Pages:   459
Publication Date:   13 June 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Using QSAR Models to Predict Mitochondrial Targeting by Small Molecule Xenobiotics within Living CellsRichard W. Horobin   2. DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: An Update Volkmar Weissig, Maria Lozoya, Nusem Yu, and Gerard G.M. D’Souza   3. Synthesis and Characterization of Mitochondria-Targeted Triphenyltriphenylphosphonium Bolaamphiphiles Francesca Ceccacci, Simona Sennato, Edoardo Rossi, Raffaele Proroga, Stefano Sarti, Marco Diociaiuti, Stefano Casciardi, Valentina Mussi, Alessia Ciogli, Federico Bordi, Giovanna Mancini, and Cecilia Bombelli   4. Synthesis and Evaluation of 18F-labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging Dong-Yeon Kim and Jung-Joon Min   5. Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear beta-Phosphorylated Nitrones: Preparation, 31P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Anti-Apoptotic Properties Consuelo Petrocchi, Sophie Thétiot-Laurent, Marcel Culcasi, and Sylvia Pietri   6. Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as exomarkers of Mitochondrial Hydrogen Peroxide Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley   7. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes Parul Benien, Mohammed Almuteri, Shrey Shah, Mark Böhlke, Ahmed Mehanna, and Gerard G. M. D’Souza   8. Imaging Mitochondrial Hydrogen Peroxide in Living Cells Alexander R. Lippert, Bryan C. Dickinson, and Elizabeth J. New   9. Synthesis and Testing Of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi   10. Bridging the Gap between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria Fernando Cagide, Catarina Oliveira, José Teixeira,  Paulo J. Oliveira, and Fernanda Borges   11. Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis Samayita Ganguly and Tamer Elbayoumi   12. Mt-fura-2, a ratiometric Mitochondria-targeted Ca2+ sensor. Determination of spectroscopic properties and Ca2+ Imaging Assays Andrea De Nadai, Nicola Vajente, Diana Pendin, and Andrea Mattarei   13. Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs Takuya Hidaka, Hiroshi Sugiyama, and Ganesh N. Pandian   14. Targeting the Mitochondrial Genome via a MITO-Porter: Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function Yuma Yamada and Hideyoshi Harashima   15. mTRIP, an Imaging Tool to Investigate Mitochondrial DNA dynamics in Physiology and Disease at the Single-Cell Resolution Laurent Chatre and Miria Ricchetti   16. Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots Ye Zhang and Hong Bi   17. Norbormide-based Probes and their Application for Mitochondrial Imaging in Drosophila Melanogaster Alessia Forgiarini , Zifei Wang , Sergio Bova, Margaret Anne Brimble, Brian Hopkins 3, David Rennison, and Genny Orso   18. Live-cell Assessment of Reactive Oxygen Species Levels Using Dihydroethidine Sander Grefte and Werner J.H. Koopman   19. Protein Supercomplex Recording In Living Cells Via Position-Specific Fluorescence Lifetime Sensors Bettina Rieger and Karin B. Busch   20. Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid Jacek Zielonka, Adam Sikora, Radoslaw Podsiadly, Micael Hardy, and B. Kalyanaraman   21. Mitochondrial Coenzyme Q10 Determination via Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry Erik Hedman and Outi Itkonen   22. Janus-type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting Maria Rocio Villegas, Victoria Lopez, Verónica Rodríguez-García, Alejandro Baeza, and María Vallet-Regí   23. Split Green Fluorescent Protein-Based Contact Site Sensor (SPLICS) for Heterotypic Organelle Juxtaposition as Applied to ER – Mitochondria Proximities Tito Calì and Marisa Brini   24. Qualitative Characterization of the Rat liver Mitochondrial Lipidome using All Ion Fragmentation on an Exactive Benchtop Orbitrap MS Irina G. Stavrovskaya, Rose M. Gathungu, Susan S. Bird, and Bruce S. Kristal   25. Live Imaging of Mitochondria in Kidney Tissue Milica Bugarski, Susan Ghazi, and Andrew M Hall   26. Time-resolved Imaging of Mitochondrial Flavin Fluorescence and Its Applications for Evaluating the Oxidative State in Living Cardiac Cells Marcek Chorvatova A., Cagalinec M., and Chorvat D Jr.   27. Mito-SinCe2 Approach to Analyze Mitochondrial Structure-Function In Single Cells Spurlock B and Mitra K   28. Computer-aided Prediction of Protein Mitochondrial Localization Pier Luigi Martelli, Castrense Savojardo, Piero Fariselli, Giacomo Tartari, and Rita Casadio

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