Overview

Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.

Full Product Details

Author:   Keshav K. Singh
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1998
Dimensions:   Width: 17.00cm , Height: 2.30cm , Length: 24.40cm
Weight:   0.748kg
ISBN:  

9783662125113

ISBN 10:   3662125110
Pages:   412
Publication Date:   11 January 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Introduction.- 2. Mitochondrial Structure, Function and Biogenesis.- 3. The Mitochondrial Genetic System.- 4. Inheritance of Mitochondrial Mutations.- 5. Mitochondrial DNA Replication.- 6. Genetic Integrity of the Mitochondrial Genome.- 7. Modeling Mitochondrial DNA Mutations.- 8. Mitochondrial Regulation of Apoptosis.- 9. Characteristics of Mitochondrial DNA Diseases.- 10. Nuclear Defects Affecting Mitochondrial Function.- 11. Mitochondrial DNA Mutations in Aging.- 12. Mitochondrial DNA Mutations and Heart Disease.- 13. Mitochondrial Dysfunction and Neurodegenerative Diseases.- 14. Toxin Induced Mitochondrial Dysfunction and Neurodegeneration.- 15. Perspectives on Mitochondria in Carcinogenesis.- 16. The Mitochondrion as a Target for Cancer Chemotherapy.- 17. Prohibitin: Mitochondrial Tumor Suppressor Protein.- 18. Abnormal Growth and Male Sterility Associated with Mitochondrial DNA Rearrangements in Plants.- 19. Mitochondrial Disorder and Migraine.- 20. Gene Therapy of Mitochondrial DNA Diseases.- Color Figures.

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