Overview

Microsatellites are short stretches of repeated DNA, found in most genomes, that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for most applications, including genetic mapping and studies of the evolutionary connections between species and populations. This book brings together an international group of scientists working in microsatellites. Their contributions provide a description of microsatellite biology, focusing on their mutation properties, generation, decay, and possible functional roles. They introduce the theoretical models that underpin the most popular methods for analyzing the information that microsatellites can yield, including methods for estimating coalescent times, population divergences and migration. Finally, the book describes the various ways in which the potential of microsatellites is being harnessed in a range of applications including medical genetics, forensics, genetic mapping, the analysis of human evolution and conservation genetics. This book is intended for graduate students and researchers in evolutionary biology and anyone using or considering the use of genetic markers - researchers in ecology, evolution, anthropology, medical genetics, molecular biology, behaviour and forensic science.

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9780198504085

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