Overview
Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include: Microbial pathogenesis at the proteome level Whole cell modeling Structural proteomics and computational analysis Biomolecular interactions Physiological proteomics Metabolic reconstruction using proteomics data While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed. Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.
Full Product Details
Author: Ian Humphery-Smith (University of Utrecht, The Netherlands) ,
Michael Hecker (Ernst-Moritz-Arndt-University of Greifswald, Germany)
Publisher: John Wiley & Sons Inc
Imprint: Wiley-Interscience
Dimensions:
Width: 18.30cm
, Height: 3.20cm
, Length: 26.20cm
Weight: 1.089kg
ISBN: 9780471699750
ISBN 10: 0471699756
Pages: 530
Publication Date: 29 September 2006
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Out of Print
Availability: Out of stock
Reviews
The authors have provided a thorough overview of what is still a relatively new field of study. (CHOICE, January 2007)
Author Information
IAN HUMPHERY-SMITH, PHD, is the Founding Chair of the Department of Pharmaceutical Proteomics at Utrecht University. Dr. Humphery-Smith has served as director of the Centre for Proteome Research and Gene-Product Mapping and served as managing director and chief scientific officer of Glaucus Proteomics BV. MICHAEL HECKER, PHD, is Professor of Microbiology and Head of the Institute for Microbiology at Ernst-Moritz-Arndt-University of Greifswald in Germany. Dr. Hecker is currently Vice Chair of the International Union of Microbiological Societies (IUMS).
