Overview
Microbial physiology, biochemistry, and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in Academia and industry.
Full Product Details
Author: G.N. Cohen
Publisher: Springer
Imprint: Springer
Edition: Softcover reprint of hardcover 1st ed. 2004
Dimensions:
Width: 21.00cm
, Height: 2.00cm
, Length: 29.70cm
Weight: 0.923kg
ISBN: 9789048163908
ISBN 10: 9048163900
Pages: 333
Publication Date: 01 December 2010
Audience:
Professional and scholarly
,
Professional & Vocational
Replaced By: 9789401789073
Format: Paperback
Publisher's Status: Active
Availability: Out of stock
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.
Reviews
The author of this book, Georges N. Cohen, is internationally recognized as an expert in the field of microbiology and as a teacher of courses in intermediary metabolism in a number of different countries. This book attests to his breadth of knowledge in these areas of science. Presented here is a comprehensive summary of current knowledge in the field of cellular metabolism with a strong emphasis on basic mechanisms of carbohydrate, purine, pyrimidine, lipid, amino acid, nucleic acid, and vitamin biochemistry. Earl R. Stadtman, National Heart, Lung and Blood Institute, Bethesda, USA
"""The author of this book, Georges N. Cohen, is internationally recognized as an expert in the field of microbiology and as a teacher of courses in intermediary metabolism in a number of different countries. This book attests to his breadth of knowledge in these areas of science. Presented here is a comprehensive summary of current knowledge in the field of cellular metabolism with a strong emphasis on basic mechanisms of carbohydrate, purine, pyrimidine, lipid, amino acid, nucleic acid, and vitamin biochemistry."" Earl R. Stadtman, National Heart, Lung and Blood Institute, Bethesda, USA"
The author of this book, Georges N. Cohen, is internationally recognized as an expert in the field of microbiology and as a teacher of courses in intermediary metabolism in a number of different countries. This book attests to his breadth of knowledge in these areas of science. Presented here is a comprehensive summary of current knowledge in the field of cellular metabolism with a strong emphasis on basic mechanisms of carbohydrate, purine, pyrimidine, lipid, amino acid, nucleic acid, and vitamin biochemistry. Earl R. Stadtman, National Heart, Lung and Blood Institute, Bethesda, USA
