Overview

Microarray technology is a major experimental tool for functional genomic explorations, and should continue to be a major tool throughout the 21st century. The explosion of this technology threatens to overwhelm the scientific community with massive quantities of data, but because microarray data analysis is an emerging field, very few analytical models exist. In this text, readers can learn about up-to-date methods, ranging from data normalization, feature selection, and discriminative analysis to machine learning techniques. The book focuses on a single data set, using a different method of analysis in each chapter. Real examples expose the strengths and weaknesses of each method for a given situation, aimed at helping readers choose appropriate protocols and utilize them for their own data set. In addition, web links are provided to the programs and tools discussed in several chapters.

Full Product Details

Author:   Simon M. Lin ,  Kimberly F. Johnson
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2002 ed.
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   1.110kg
ISBN:  

9781402071119

ISBN 10:   1402071116
Pages:   214
Publication Date:   30 June 2002
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

An Introduction to DNA Microarrays.- Experimental Design for Gene Microarray Experiments and Differential Expression Analysis.- Microarray Data Processing and Analysis.- Biology-driven Clustering of Microarray Data.- Extracting Global Structure from Gene Expression Profiles.- Supervised Neural Networks for Clustering Conditions in DNA Array Data After Reducing Noise by Clustering Gene Expression Profiles.- Bayesian Decomposition Analysis of Gene Expression in Yeast Deletion Mutants.- Using Functional Genomic Units to Corroborate User Experiments with the Rosetta Compendium.- Fishing Expedition - a Supervised Approach to Extract Patterns from a Compendium of Expression Profiles.- Modeling Pharmacogenomics of the NCI-60 Anticancer Data Set: Utilizing Kernel Pls to Correlate the Microarray Data to Therapeutic Responses.- Analysis of Gene Expression Profiles and Drug Activity Patterns by Clustering and Bayesian Network Learning.- Evaluation of Current Methods of Testing Differential Gene expression and Beyond.- Extracting Knowledge from Genomic Experiments by Incorporating the Biomedical Literature.

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Author Information

Simon M. Lin is Manager of Duke Bioinformatics Shared Resource, Duke University Medical Center. Kimberly F. Johnson is Director of Duke Cancer Center Information Systems and Director of Duke Bioinformatics Shared Resource, Duke University Medical Center.

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