Overview
The only up-to-date compilation of renal methods available, this book is the definitive resource for any renal researcher eager to stay ahead. Methods in Renal Toxicology presents a vast array of methods for the study of renal cellular and tubular structure, function, and biochemistry under physiological, toxicological, and pathological conditions. It provides detailed descriptions in easy-to-understand language of methods designed to enhance your research efforts.Methods in Renal Toxicology puts you on the cutting edge with valuable chapters detailing molecular methods and transgene and gene targeting - the most recent approaches to the study of renal toxicology. Overall, the book's topics range from non-invasive assessments of renal function in the whole animal and clinical settings to cellular and molecular approaches. Specifically, the book delves into measurements of clearance and urinary markers, histopathology, and methods to assess renal carcinogenesis, mutagenesis, oxidative stress, mitochondria injury, cellular repair, and drug metabolism and transport. A variety of in vitro methods are also described, including the isolated perfused kidney, micropuncture, microperfusion, microdissection, renal slices, isolated perfused tubules, suspensions of tubules and isolated cells, and primary cell cultures and cell lines. Methods in Renal Toxicology is a must-have resource for all renal investigators. Nowhere else can you find concise descriptions of traditional and up-to-the-minute renal toxicology methods in such a practical, well-written single-volume guide.
Full Product Details
Author: Rudolfs K. Zalups (Mercer University School of Medicine, Macon, Georgia, USA) , Lawrence H. Lash (Wayne State Univ School of Medicine, Detroit, Michigan, USA)
Publisher: Taylor & Francis Inc
Imprint: CRC Press Inc
Dimensions:
Width: 17.80cm
, Height: 2.50cm
, Length: 25.40cm
Weight: 1.225kg
ISBN: 9780849333415
ISBN 10: 0849333415
Pages: 448
Publication Date: 14 March 1996
Audience:
Professional and scholarly
,
Professional and scholarly
,
Professional & Vocational
,
Professional & Vocational
Format: Hardback
Publisher's Status: Out of Print
Availability: Out of stock 
Table of Contents
Clearance Methods in Renal Toxicology, J.B. Tarloff Urinary Markers, J.S. Woods Histopathological Methods in Renal Toxicology, N. Marcussen and J.B. Lundemose The Isolated Perfused Kidney, G.L. Diamond Micropuncture and Microperfusion Techniques, C.R. Ramesy and F.G. Knox Microdissection and Microanalysis of Specific Nephron Segments from Mammalian Kidney, E.N. Chini and T.P. Dousa Preparation and Use of Precision-Cut Renal Cortical Slices in Renal Toxicology, A.J. Gandolfi, K. Brendel, and Q. Fernando In Vitro Perfusion of Isolated Nephron Segments: A Method for Renal Toxicology, R.K. Zalups and D.W. Barfuss Suspensions of Rabbit Renal Proximal Tubules, C. E. Groves and R.G. Schnellmann Characterization and Use of Rabbit Renal Proximal Tubular Cells in Primary Culture for Toxicology Research, M.D. Aleo and P.J. Kostyniak Use of Freshly Isolated and Primary Cultures of Proximal Tubular and Distal Tubular Cells from Rat Kidney, L.H. Lash Immortalized Cell Lines of Renal Cells, M.L. Taub Methods in Renal Carcinogenesis and Mutagenesis, R.R. Misra, B.A. Diwan, D.E. Devor, J.M. Ward, and M.P. Waalkes Measurement of Reactive Oxygen Species, Oxidative Damage, and Antioxidant Systems in the Kidney, N. Ueda and S.V. Shah Mechanisms of Repair After Renal Injury, S.B. Miller Mitochondrial Toxicity in Renal Injury, L.H. Lash and D.P. Jones Biotransformation and Membrane Transport in Nephrotoxicity, P.J. Harvison and G.O. Rankin Methods to Evaluate Renal Cytochrome P450 as a Bioactivation System for Nephrotoxicants, K.J. Woodcroft, R.C. Zangar, and R.F. Novak Molecular Methods in Renal Toxicology, J. Koropatnick Transgenic Animals, S.Yee Index
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