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9783030495305

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The R source code is shown by chapter, well-documented, and easy to find and follow as brief descriptions and necessary specifications for the function calls are given by means of comments. ... a wide area of application fields is covered and exhaustive literature references for further reading are given. ... The presentation of the material is very reader-friendly, easily accessible and pedagogical ... . It is likewise highly recommended ... . This is an effective and nicely written reference textbook. (Oke Gerke, ISCB News, iscb.info, Vol. 72, December, 2021)

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Prof. Dr. Meinhard Kieser is a Professor of Medical Biometry and Director of the Institute of Medical Biometry and Informatics at the University of Heidelberg. He studied Mathematics and received his PhD in Medical Biometry in 1992. He then worked for more than 15 years as a biostatistician and Head of Biometrics in the pharmaceutical industry. Professor Kieser has comprehensive experience in the planning and analysis of clinical trials and has been a member of numerous independent data monitoring committees. He serves as an associate editor for Pharmaceutical Statistics and the Journal of Biopharmaceutical Statistics. His main research areas are biostatistical methods for clinical trials, including sample size calculation and recalculation, and methods for evidence synthesis.

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