Overview

A new volume in the Emerging Issues in Analytical Chemistry series, Methods and Advances in Traditional Chinese Medicine describes analytical chemistry methods used to characterize constituents of herbal remedies, explore their mechanisms of action singly and in concert, and support the clinical trials necessary to bring Traditional Chinese Medicine (TCM) into the mainstream of therapeutics. With recent advances in analytical instruments, molecular pharmacology, and genetics, it is now possible to investigate the bioactive molecules in a complex medicine on a rational basis. This book is the first to combine TCM with analytical chemistry methods toward this goal. The book begins with a brief history of TCM, consideration of its strengths and weaknesses, and a review of the literature on application of Western analytical methods. It continues with an examination of the concept of synergistic, multi-targeted action among components, followed by an analysis of how analytical chemistry and other methods are used to assure quality and uniformity of natural products within tolerable limits. It then addresses the complexity introduced by absorption, distribution, and metabolism of an already complex drug. The last chapter advocates a system biological approach as the way forward for drug discovery and development in TCM. The Emerging Issues in Analytical Chemistry series is published in partnership with RTI International and edited by Brian F. Thomas. Please be sure to check out our other featured volumes: * Thomas, Brian F. and ElSohly, Mahmoud. The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations, 9780128046463, December 2015.* Hackney, Anthony C. Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice, 9780128092064, March 2016.* Tanna, Sangeeta and Lawson, Graham. Analytical Chemistry for Assessing Medication Adherence, 9780128054635, April 2016.* Rao, Vikram, Knight, Rob, and Stoner, Brian. Sustainable Shale Oil and Gas: Analytical Chemistry, Biochemistry, and Geochemistry Methods, 9780128103890, forthcoming September 2016.* Farsalinos, Konstantinos, et al. Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles, 9780128112410, forthcoming November 2016. * Emphasizes the advantages of combining traditional medicine and modern tools for drug discovery and development* Provides examples which source, identify, and assay materials; describe preparation of complex remedies and isolate or synthesize their components; characterize complexes and derivatives; and test selected entities for efficacy in animals and humans* Explains the capabilities and limitations of various methods for evaluating test results, establishing the parameters of quality assurance

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9780128051610

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Dr. Lee has more than 40 years of experience in natural products chemistry, with a focus on Chinese herbal medicine. He has been principal investigator for numerous laboratory and clinical research studies funded by the U.S. National Institutes of Health and other agencies. He has been director of the Bio-Organic and Natural Products Research Laboratory since its foundation in 1999, has published 110 papers and 2 book chapters, and holds 15 patents. He is associate editor of Traditional Chinese Medicine and Journal of Traditional and Complementary Medicine. Professor Bi has been working in pharmacy education and scientific research for more than 30 years. His research is focused on drug quality control; modernization of traditional Chinese medicine, pharmacokinetics and metabonomics. He has published 3 professional teaching books, 2 monographs, and more than 160 papers cited by Science Citation Index. He has served on the Chinese Pharmacopoeia Commission and the National New Drug Evaluation Committee of the Food and Drug Administration of China, as an evaluation expert of the Natural Science Foundation of China, and in many other capacities. Dr. Dai received her Ph.D. in pharmaceutical analysis at Shenyang Pharmaceutical University in 2004. Her research is focused on development of analytical methods for determination of drugs and metabolites in biological samples. She has been principle investigator for metabolism studies of traditional Chinese medicines funded by the National Natural Science Foundation of China. She has published more than 30 papers and 2 book chapters. Dr. Pollard has been a behavioural pharmacologist in the pharmaceutical industry for more than 40 years, first with a major pharmaceutical company and since 1995 as a partner in Howard Associates, a contract research company. He has more than 40 scientific publications. Now specializing in writing and editing, he is certified ELS by the Board of Editors in the Life Sciences and is an associate editor of the book series Emerging Issues in Analytical Chemistry.

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