Overview
The number of people infected with HIV or living with AIDS is increasing at unprecedented rates as various scientists, organizations, and institutions search for innovative solutions to combating and preventing the disease. At the request of the Bill & Melinda Gates Foundation, Methodological Challenges in Biomedical HIV Prevention Trials addresses methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials. This book recommends a number of ways to improve the design, monitoring, and analysis of late-stage clinical trials that evaluate nonvaccine biomedical interventions. The objectives include identifying a beneficial method of intervention, enhancing quantification of the impact, properly assessing the effects of using such an intervention, and reducing biases that can lead to false positive trial results. According to Methodological Challenges in Biomedical HIV Prevention Trials, the need to identify a range of effective, practical, and affordable preventive strategies is critical. Although a large number of promising new HIV prevention strategies and products are currently being tested in late-stage clinical trials, these trials face a myriad of methodological challenges that slow the pace of research and limit the ability to identify and fully evaluate effective biomedical interventions. Table of Contents Front Matter Summary Introduction 1 The Status and Challenges of Biomedical HIV Prevention Trials 2 Basic Design Features: Size, Duration, and Type of Trials, and Choice of Control Group 3 Design Considerations: Risk-Reduction Counseling 4 Design Considerations: Pregnancy 5 Design Considerations: Adherence 6 Design Considerations: Recruitment and Retention 7 Site Preparedness 8 Estimating HIV Incidence 9 Interim Monitoring and Analysis of Results 10 Alternative Designs Appendix A: Public Committee Meeting Agendas Appendix B: Acronyms Appendix C: Supporting Materials for Chapter 2 Appendix D: Methods for Analyzing Adherence Appendix E: Committee Biographies
Full Product Details
Author: Institute of Medicine ,
Board on Global Health ,
Committee on the Methodological Challenges in HIV Prevention Trials ,
Alicia R. Gable
Publisher: National Academies Press
Imprint: National Academies Press
Dimensions:
Width: 15.20cm
, Height: 1.50cm
, Length: 22.90cm
Weight: 0.431kg
ISBN: 9780309114301
ISBN 10: 0309114306
Pages: 270
Publication Date: 13 June 2008
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: Awaiting stock
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Author Information
Stephen W. Lagakos and Alicia R. Gable, Editors, Committee on the Methodological Challenges in HIV Prevention Trials
