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Author:   Martin Schumacher ,  Gabriele Schulgen-Kristiansen
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   3., überarb. Aufl. 2008
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.730kg
ISBN:  

9783540851356

ISBN 10:   3540851356
Pages:   436
Publication Date:   23 September 2008
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Language:   German

Table of Contents

Kontrollierte klinische Studien - eine Einführung.- Zur Notwendigkeit randomisierter Studien: Hochdosis-Chemotherapie beim Mammakarzinom.- Auswertung.- Statistische Analyse eines quantitativen Zielkriteriums - Kann durch eine Fischdiät der Cholesterinspiegel gesenkt werden?.- Statistische Analyse eines qualitativen Zielkriteriums - Auswertung einer klinischen Studie zur Behandlung des akuten Herzinfarkts.- Analyse von Ereigniszeiten - Teil I.- Analyse von Ereigniszeiten - Teil II.- Die Beurteilung der Gleichwertigkeit von Behandlungen.- Meta-Analyse randomisierter klinischer Studien, Publikationsbias und evidenzbasierte Medizin.- Intention-to-Treat Analyse.- Planung und Durchführung.- Planung einer klinischen Studie: Wie viele Patienten sind notwendig?.- Randomisation und Verblindung.- Zwischenauswertungen und statistisches Monitoring der Ergebnisse von klinischen Studien.- Datenmanagement in klinischen Studien.- Qualitätsanforderungen.- Qualitätsanforderungen an die biometrische Planung und Auswertung klinischer Studien.- Qualitätsanforderungen an die Durchführung klinischer Studien.- Spezielle Designs.- Planung und Auswertung von Phase I und II Studien.- Cross-Over Studien.- Diagnosestudien: Wertigkeit der Sonographie bei der Differenzierung von gut- und bösartigen Brusttumoren bei Patientinnen mit klinischen Symptomen.- Prognosestudien: Beurteilung potentieller prognostischer Faktoren.- Spezielle Probleme.- Die Problematik von Subgruppenanalysen in klinischen Studien: Eine hypothetische klinische Studie beim Mammakarzinom.- Multiples Testen.- Ereigniszeiten und konkurrierende Risiken – zur Planung und Auswertung der 4D -Studie.

Reviews

<p>From the reviews of the second edition: <p><p> It gives an introduction into the methodology of clinical trials for researchers and students which is adequate for self-study and also for readers with a non-statistical background. The book deals with the different aspects of clinical trials: statistical analysis, planning and conduct of clinical trials, quality requirements, and presents also examples of special designs for clinical studies. The reader can also find numerous references at the end of each chapter as well as hints to helpful websites and useful software. (Christina Wunder, Zentralblatt MATH, Vol. 1119 (21), 2007)

From the reviews of the second edition: <p> It gives an introduction into the methodology of clinical trials for researchers and students which is adequate for self-study and also for readers with a non-statistical background. The book deals with the different aspects of clinical trials: statistical analysis, planning and conduct of clinical trials, quality requirements, and presents also examples of special designs for clinical studies. a ] The reader can also find numerous references at the end of each chapter as well as hints to helpful websites and useful software. (Christina Wunder, Zentralblatt MATH, Vol. 1119 (21), 2007)

From the reviews of the second edition: It gives an introduction into the methodology of clinical trials for researchers and students which is adequate for self-study and also for readers with a non-statistical background. The book deals with the different aspects of clinical trials: statistical analysis, planning and conduct of clinical trials, quality requirements, and presents also examples of special designs for clinical studies. The reader can also find numerous references at the end of each chapter as well as hints to helpful websites and useful software. (Christina Wunder, Zentralblatt MATH, Vol. 1119 (21), 2007)

From the reviews of the second edition: </p> It gives an introduction into the methodology of clinical trials for researchers and students which is adequate for self-study and also for readers with a non-statistical background. The book deals with the different aspects of clinical trials: statistical analysis, planning and conduct of clinical trials, quality requirements, and presents also examples of special designs for clinical studies. The reader can also find numerous references at the end of each chapter as well as hints to helpful websites and useful software. (Christina Wunder, Zentralblatt MATH, Vol. 1119 (21), 2007)</p>

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