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OverviewMetallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events. Full Product DetailsAuthor: Paolo Zatta (Univ Of Padova, Italy)Publisher: World Scientific Publishing Co Pte Ltd Imprint: World Scientific Publishing Co Pte Ltd Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.10cm Weight: 0.635kg ISBN: 9789812778932ISBN 10: 9812778934 Pages: 336 Publication Date: 22 October 2008 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Out of stock ![]() The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsMetallothioneins and Neurological Disorders: Chemical Structure of Metallothionein (M Vasak); MT and Oxidative Stress (W Maret); MT in Neurodegenerative Diseases (P Zatta); MT in Brain Inflammation (J Hidalgo & M Penkowa); MT and Autism (M Aschner); MT and Neuronal Injury (R S Chung & A West); Metallothionein in Oncology: MT in Oncology (S E Theocharis); MT and Melanoma (G Weinlich); MT and Brest Cancer (B-H Bay); MT and Prostate Cancer (C Balaji); MT and Colorectal Tumors (N Aoyama); Metallothionein in Cardiopathy: Metallothionein in Cardiomyopathy (L Cai); Metallothionein and Atherosclerosis (E Moccheggiani).ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |