Metallothioneins In Biochemistry And Pathology

Author:   Paolo Zatta (Univ Of Padova, Italy)
Publisher:   World Scientific Publishing Co Pte Ltd
ISBN:  

9789812778932


Pages:   336
Publication Date:   22 October 2008
Format:   Hardback
Availability:   Out of stock   Availability explained
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Metallothioneins In Biochemistry And Pathology


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Overview

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Full Product Details

Author:   Paolo Zatta (Univ Of Padova, Italy)
Publisher:   World Scientific Publishing Co Pte Ltd
Imprint:   World Scientific Publishing Co Pte Ltd
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.10cm
Weight:   0.635kg
ISBN:  

9789812778932


ISBN 10:   9812778934
Pages:   336
Publication Date:   22 October 2008
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Metallothioneins and Neurological Disorders: Chemical Structure of Metallothionein (M Vasak); MT and Oxidative Stress (W Maret); MT in Neurodegenerative Diseases (P Zatta); MT in Brain Inflammation (J Hidalgo & M Penkowa); MT and Autism (M Aschner); MT and Neuronal Injury (R S Chung & A West); Metallothionein in Oncology: MT in Oncology (S E Theocharis); MT and Melanoma (G Weinlich); MT and Brest Cancer (B-H Bay); MT and Prostate Cancer (C Balaji); MT and Colorectal Tumors (N Aoyama); Metallothionein in Cardiopathy: Metallothionein in Cardiomyopathy (L Cai); Metallothionein and Atherosclerosis (E Moccheggiani).

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