Metallocofactors that Activate Small Molecules: With Focus on Bioinorganic Chemistry

Author:   Markus W. Ribbe
Publisher:   Springer Nature Switzerland AG
Edition:   1st ed. 2019
Volume:   179
ISBN:  

9783030258993


Pages:   169
Publication Date:   25 September 2020
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Metallocofactors that Activate Small Molecules: With Focus on Bioinorganic Chemistry


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Author:   Markus W. Ribbe
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2019
Volume:   179
Weight:   0.454kg
ISBN:  

9783030258993


ISBN 10:   3030258998
Pages:   169
Publication Date:   25 September 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1. Looking at Nitrogenase: Insights from Modern Structural Approaches.- Chapter 2. Current Understanding of the Biosynthesis of the Unique Nitrogenase Cofactor Core.- Chapter 3. Recent Advances in the Chemical Synthesis of Nitrogenase Model Clusters.- Chapter 4. The Catalytic Mechanisms of the Molybdenum and Tungsten Enzymes.- Chapter 5. The Role of the Pyranopterin Dithiolene Component of Moco in Molybdoenzyme Catalysis.- Chapter 6. Mechanism of Ni,Fe-Containing Carbon Monoxide Dehydrogenases.

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The focus of Dr. Ribbe’s research is the assembly and mechanism of nitrogenase, one of the most complex metalloenzymes known to date. Nitrogenase can be appreciated from the perspective of the useful agricultural and industrial products it generates, namely, ammonia, hydrogen and hydrocarbons. Since the beginning of his independent career, Dr. Ribbe has focused his efforts on investigating the biosynthesis of the Mo-nitrogenase from Azotobacter vinelandii and, in particular, the unique metal centers of its MoFe protein component: FeMoco and P-cluster. Results of these studies have firmly established nitrogenase MoFe protein as a model system that could be used to deduce the general mechanism of metal cluster assembly and develop successful strategies for synthesizing bio-inspired catalysts for industrial usage. Recently, Dr. Ribbe expanded his research to the investigation of the structure and function of the “alternative” V-nitrogenase from Azotobacter vinelandii. His discovery that V-nitrogenase can convert CO to hydrocarbons provides a potential blueprint for developing cost-efficient processes for industrial production of biofuels in the future.

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