Overview

Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts.

Full Product Details

Author:   Astrid Sigel (University of Basel, Switzerland) ,  Helmut Sigel (University of Basel, Switzerland)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   33
Dimensions:   Width: 21.00cm , Height: 3.70cm , Length: 28.00cm
Weight:   1.088kg
ISBN:  

9780824796884

ISBN 10:   0824796888
Pages:   728
Publication Date:   29 February 1996
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Molecular modelling of transition metal adducts with nucleic acids and their constituents; zinc complexes as targeting agents for nucleic acids; metallocene interactions with DNA and DNA processing enzymes; evidences for a catalytic activity of the DNA double helix in the reactions between DNA, platinum (II) and intercalators; trans-diammineplatinum (II) - what makes it different from CIS-DDP? coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids; metal ions in multiple-stranded DNA; DNA interactions with substitution-intert transition metal ion complexes; effect of metal ions on the fluorescence of dyes bound to DNA; photolytic covalent binding of metal complexes to DNA; electrochemically activated nucleic acid oxidation; electron transfer between metal complexes bound to DNA - is DNA a wire?; porphyrin and metalloporphyrin interactions with DNA; selective DNA cleavage by metalloporphyrin derivatives; synthetic metalloporphyrins as probes of protein-DNA interactions; targeting of nucleic acids by iron complexes; nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives; specific DNA cleavage by manganese (III) complexes; nickel complexes as probes of guanine sites in nucleic acid folding; hydrolytic cleavage of RNA catalyzed by metal ion complexes; RNA recognition and cleavage by iron (III)-bleomycin; metallobleomycin-DNA interactions - structures and reactions related to bleomycin-induced DNA damage.

Reviews

. . .draws on the experience of recognized international experts to review the present status of research in this area. . . . . .a very useful volume, complementing Volume 32. . .recommended to all those with an interest in this area of bioinorganic chemistry. ---Platinum Metals Review

. . .draws on the experience of recognized international experts to review the present status of research in this area. . . . . .a very useful volume, complementing Volume 32. . .recommended to all those with an interest in this area of bioinorganic chemistry. ---Platinum Metals Review

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions