Overview

The main theme of the symposium reported in this book was the presentation and discussion of the direct and indirect evidence available on the three-dimensional structure of membrane proteins and on the interactions relevant to their functioning. Among the topics discussed are the lessons of the known 3D structures, the prospects in 3D structure determination (by X-rays, electron microscopy, neutron scattering, NMR, optical methods, site-directed mutagenesis, theoretical calculations and modeling, etc) and the interactions with lipids. The originality of the Symposium, reflected in the content of the book, was to bring together well-known specialists in the biochemistry of the proteins considered (bacteriorhodopsin, receptors, acetylcholine esterase, glycophorine, porines, etc) and experts in the physicochemical, chemical and theoretical methods utilized.

Full Product Details

Author:   A. Pullman ,  Joshua Jortner ,  A. Pullman
Publisher:   Springer
Imprint:   Springer
Edition:   1992 ed.
Volume:   25
Dimensions:   Width: 15.50cm , Height: 3.30cm , Length: 23.50cm
Weight:   1.035kg
ISBN:  

9780792319511

ISBN 10:   0792319516
Pages:   506
Publication Date:   31 October 1992
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Electron Crystallography of Membrane Proteins 1.- High-Resolution Electron Microscopy of Membrane Proteins.- Distinguishing Transmembrane Helices from Peripheral Helices by Circular Dichroism.- High-Resolution NMR of Membrane Proteins: the Example of Bacteriorhodopsin.- Molecular Dynamics Simulations of Bacteriorhodopsin.- Dynamics of Bacteriorhodopsin Studied by Neutron Scattering: Effects of the Environment, Softness and Structure.- What do Neutrons, X-Ray Synchrotron Radiation, Optical pH-Indicators, and Mutagenesis tell us about the Light-Driven Proton Pump Bacteriorhodopsin ?.- From Time-Resolved Difference Spectra to Kinetics, Mechanism, and Thermodynamics in the Bacteriorhodopsin Photocycle.- Arginine 175 is Part of an Anion Binding Site in Bacteriorhodopsin.- Electrostatic Calculations of the pKa’s of Ionizable Groups in Bacteriorhodopsin.- Dimerization of Glycophorin A Transmembrane Helices: Mutagenesis and Modeling.- The Nicotinic Acetylcholine Receptor, a Model of Ligand-Gated Ion Channels: Investigation of its Functional Organization by Protein Chemistry and Site-Directed Mutagenesis.- Molecular Evolution of the Binding Site of the Nicotinic Acetylcholine Receptor.- 3-D Structure of Acetylcholinesterase and Complexes of it with Anticholinesterase Agents.- Modelling and Mutagenesis of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase.- The Nicotinic Acetylcholine Receptor and its Lipid Microenvironment.- A Correlation Between Patch Clamp and Fluorescence Anisotropy Experiments to Study Alterations on the Acethylcholine Channel Induced by Cholesterol Enrichment in Chick Myocytes.- Interaction of the Nicotinic Acetylcholine Receptor with Ligands and Membrane Lipids Studied by Fourier-Transform Infrared Spectroscopy and PhotoaffinityLabeling.- On the Complexation of the Methylammonium Ion by Aromatic Side Chains of Proteins.- The Inhibitory Glycine Receptor: Structure-Function Studies on a Neuronal Chloride Channel.- Determinants of Ligand Binding to the Inhibitory Glycine Receptor.- Channel Proteins: from Anatomy to Design.- Linking Permeation Behavior and Structure of Ion Channels with a Microscopic Model.- Molecular Structure-Function Relations in Voltage-Gated Ion Channels of Excitable Membranes.- A Novel Model for Saturation of Ion Conductivity in Transmembrane Channels.- Computational Approaches to Understanding the Ion Channel-Lipid System.- A Minimal Model of Ion Channels: Polyamino Acids in Liposomes.- Structure and Dynamics of Melittin in Solution and Membranes from Amide Hydrogen Exchange Analysis.- Computer Modelling of Ion Binding Sites in Proteins.- Sec-Dependent and Sec-Independent Mechanisms of Protein Insertion into Bacterial Membranes.- Puncturing Cell Membranes: Comparison of Colicin A and Aerolysin.- Structure-Function Relationships in the Membrane Channel Porin as Based on a 1.8 A Resolution Crystal Structure.- Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins.- Preliminary Structural Studies of Photosystem I.- Problems and Progress in Computational Approaches to the Molecular Basis of Recognition.- Assembly of Escherichia Coli Inner Membrane Proteins: Sec-Dependent and Sec-Independent Membrane Insertion.- Molecular Dynamics Simulations of Phospholipid Membranes and their Interaction with Phospholipase A2.- Electron Transfer in Bacterial Photosynthetic Reaction Centers.- Proton Transfer Pathways in Photosynthetic Reaction Centers Studied by Site-Directed Mutagenesis.

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