Overview

Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs. Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia. This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations.

Full Product Details

Author:   Dale J. Benos (Department of Physiology and Biophysics, University of Alabama, Birmingham, USA) ,  David W. Deamer (University of California, Santa Cruz, U.S.A.) ,  Arnost Kleinzeller (University of Pennsylvania School of Medicine, Philadelphia, U.S.A.) ,  Douglas M. Fambrough (The Johns Hopkins University, Baltimore, Maryland, U.S.A.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   v. 48
Dimensions:   Width: 15.20cm , Height: 2.80cm , Length: 22.90cm
Weight:   0.690kg
ISBN:  

9780121533489

ISBN 10:   0121533484
Pages:   423
Publication Date:   21 May 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

A. Kleinzeller, Overton's Concept of a Cell Membrane. T.J. McIntosh, Structure and the Physical Properties of the Lipid Membrane. A. Pohorille, M.H. New, K. Schweighofer, and M.A. Wilson, Insights from Computer Simulations into the Interactions of Small Molecules with Lipid Bilayers. D.W. Deamer and S. Paula, The Permeability Barriers to Ions and Polar Solutes. A.S. Verkman, Water Permeation Across Membranes. E.K. Hoffmann and J.W. Mills, Membrane Events Involved in Volume Regulation. D.S. Cafiso, The Interaction of Natural and Model Peptides with Membranes. M. Saxton, Lipid-Peptide Diffusion in Membranes. C.M. Armstrong, A Short History of Ion Channels and Signal Propagation. K. Miller, W. Sandberg, and B. Dubois, The Lipid Membrane and Ligand-Gated Ion Channels in General Anesthetic Action. S.M. Robbins and M. Hollenberg, Plasma Membrane-Localized Signal Transduction. R.L. Post, Active Transport and Pumps.

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