Overview

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during ageing and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lips including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in ageing and age-related disease.

Full Product Details

Author:   M.P. Mattson (Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Volume:   v. 12
Dimensions:   Width: 21.00cm , Height: 1.60cm , Length: 27.90cm
Weight:   0.730kg
ISBN:  

9780444512970

ISBN 10:   0444512977
Pages:   236
Publication Date:   06 May 2003
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1. Overview: Spatial control of signal transduction by caveolae and lipid rafts (C.J. Fielding). 2. Overview: Membrane lipid peroxidation (K. Montine, J. Quinn, T. Montine). 3. Regulation of invertebrate longevity by inositol phosphate signaling (C. Wolkow). 4. Ceramide-driven stress signals in cancer and aging (P.P. Ruvolo, C. Johnson, W.D. Jarvis). 5. Sphingolipid metabolism and signaling in atherosclerosis (S. Chatterjee, S. Martin). 6. Sphingolipid and ceramide in brain aging, neuronal plasticity and neurodegenerative disorders (M.P. Mattson, R.G. Cutler). 7. The eicosanoid pathway and brain aging (H. Manev, T. Uz). 8. Cellular cholesterol, membrane signaling and disease (J.P. Incardona). 9. Cholesterol, &bgr;-amyloid, and Alzheimer's disease (S. Petanceska, M.A. Pappolla et al.). 10. Phospholipase A2 in the pathogenesis of cardiovascular disease (E. Hurt-Camejo, P. Sartipy et al.). 11. Retinal docosahexaenoic acid, age-related diseases and glaucoma (N.G. Bazan, E. Rodriguez).

Reviews

.. .This is an impressive series of multi-author books, edited by Mark Mattson of the National Institute on Aging, and covers a wide range of topics within the molecular and cell biology of aging, age-related diseases and programmed cell death.

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